Is There a Role for Hematopoietic Growth Factors During Sepsis?

Sepsis is a complex syndrome characterized by simultaneous activation of pro- and anti-inflammatory processes. After an inflammatory phase, patients present signs of immunosuppression and possibly persistent inflammation. Hematopoietic growth factors (HGFs) are glycoproteins that cause immune cells...

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Detalles Bibliográficos
Autores principales: Chousterman, Benjamin G., Arnaud, Marine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021493/
https://www.ncbi.nlm.nih.gov/pubmed/29977234
http://dx.doi.org/10.3389/fimmu.2018.01015
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author Chousterman, Benjamin G.
Arnaud, Marine
author_facet Chousterman, Benjamin G.
Arnaud, Marine
author_sort Chousterman, Benjamin G.
collection PubMed
description Sepsis is a complex syndrome characterized by simultaneous activation of pro- and anti-inflammatory processes. After an inflammatory phase, patients present signs of immunosuppression and possibly persistent inflammation. Hematopoietic growth factors (HGFs) are glycoproteins that cause immune cells to mature and/or proliferate. HGFs also have a profound effect on cell functions and behavior. HGFs play crucial role in sepsis pathophysiology and were tested in several clinical trials without success to date. This review summarizes the role played by HGFs during sepsis and their potential therapeutic role in the Management of sepsis-related immune disturbances.
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spelling pubmed-60214932018-07-05 Is There a Role for Hematopoietic Growth Factors During Sepsis? Chousterman, Benjamin G. Arnaud, Marine Front Immunol Immunology Sepsis is a complex syndrome characterized by simultaneous activation of pro- and anti-inflammatory processes. After an inflammatory phase, patients present signs of immunosuppression and possibly persistent inflammation. Hematopoietic growth factors (HGFs) are glycoproteins that cause immune cells to mature and/or proliferate. HGFs also have a profound effect on cell functions and behavior. HGFs play crucial role in sepsis pathophysiology and were tested in several clinical trials without success to date. This review summarizes the role played by HGFs during sepsis and their potential therapeutic role in the Management of sepsis-related immune disturbances. Frontiers Media S.A. 2018-06-21 /pmc/articles/PMC6021493/ /pubmed/29977234 http://dx.doi.org/10.3389/fimmu.2018.01015 Text en Copyright © 2018 Chousterman and Arnaud. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chousterman, Benjamin G.
Arnaud, Marine
Is There a Role for Hematopoietic Growth Factors During Sepsis?
title Is There a Role for Hematopoietic Growth Factors During Sepsis?
title_full Is There a Role for Hematopoietic Growth Factors During Sepsis?
title_fullStr Is There a Role for Hematopoietic Growth Factors During Sepsis?
title_full_unstemmed Is There a Role for Hematopoietic Growth Factors During Sepsis?
title_short Is There a Role for Hematopoietic Growth Factors During Sepsis?
title_sort is there a role for hematopoietic growth factors during sepsis?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021493/
https://www.ncbi.nlm.nih.gov/pubmed/29977234
http://dx.doi.org/10.3389/fimmu.2018.01015
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