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Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum
The brain is continuously active, even in the absence of external stimulation. In the optic tectum of the zebrafish larva, this spontaneous activity is spatially organized and reflects the circuit’s functional connectivity. The structure of the spontaneous activity displayed patterns associated with...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021757/ https://www.ncbi.nlm.nih.gov/pubmed/29977193 http://dx.doi.org/10.3389/fncir.2018.00046 |
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author | Marachlian, Emiliano Avitan, Lilach Goodhill, Geoffrey J. Sumbre, Germán |
author_facet | Marachlian, Emiliano Avitan, Lilach Goodhill, Geoffrey J. Sumbre, Germán |
author_sort | Marachlian, Emiliano |
collection | PubMed |
description | The brain is continuously active, even in the absence of external stimulation. In the optic tectum of the zebrafish larva, this spontaneous activity is spatially organized and reflects the circuit’s functional connectivity. The structure of the spontaneous activity displayed patterns associated with aspects of the larva’s preferences when engaging in complex visuo-motor behaviors, suggesting that the tectal circuit is adapted for the circuit’s functional role in detecting visual cues and generating adequate motor behaviors. Further studies in sensory deprived larvae suggest that the basic structure of the functional connectivity patterns emerges even in the absence of retinal inputs, but that its fine structure is affected by visual experience. |
format | Online Article Text |
id | pubmed-6021757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60217572018-07-05 Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum Marachlian, Emiliano Avitan, Lilach Goodhill, Geoffrey J. Sumbre, Germán Front Neural Circuits Neuroscience The brain is continuously active, even in the absence of external stimulation. In the optic tectum of the zebrafish larva, this spontaneous activity is spatially organized and reflects the circuit’s functional connectivity. The structure of the spontaneous activity displayed patterns associated with aspects of the larva’s preferences when engaging in complex visuo-motor behaviors, suggesting that the tectal circuit is adapted for the circuit’s functional role in detecting visual cues and generating adequate motor behaviors. Further studies in sensory deprived larvae suggest that the basic structure of the functional connectivity patterns emerges even in the absence of retinal inputs, but that its fine structure is affected by visual experience. Frontiers Media S.A. 2018-06-21 /pmc/articles/PMC6021757/ /pubmed/29977193 http://dx.doi.org/10.3389/fncir.2018.00046 Text en Copyright © 2018 Marachlian, Avitan, Goodhill and Sumbre. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Marachlian, Emiliano Avitan, Lilach Goodhill, Geoffrey J. Sumbre, Germán Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum |
title | Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum |
title_full | Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum |
title_fullStr | Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum |
title_full_unstemmed | Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum |
title_short | Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum |
title_sort | principles of functional circuit connectivity: insights from spontaneous activity in the zebrafish optic tectum |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021757/ https://www.ncbi.nlm.nih.gov/pubmed/29977193 http://dx.doi.org/10.3389/fncir.2018.00046 |
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