Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death

Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) is the rate-limiting enzyme of the mammalian NAD(+) biosynthesis salvage pathway. Using inducible and conditional knockout (cKO) mice, we show that Nampt gene deletion in adult projection neurons leads to a progressive loss of body weight...

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Detalles Bibliográficos
Autores principales: Wang, Xiaowan, Zhang, Qiao, Bao, Ruisi, Zhang, Nannan, Wang, Yingzhen, Polo-Parada, Luis, Tarim, Andrew, Alemifar, Aidan, Han, Xianlin, Wilkins, Heather M., Swerdlow, Russell H., Wang, Xinglong, Ding, Shinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021762/
https://www.ncbi.nlm.nih.gov/pubmed/28854367
http://dx.doi.org/10.1016/j.celrep.2017.08.022

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