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Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma
Pancreatic cancer (PaC) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies h...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021768/ https://www.ncbi.nlm.nih.gov/pubmed/29962812 http://dx.doi.org/10.3748/wjg.v24.i24.2537 |
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author | Llop, Esther Guerrero, Pedro E Duran, Adrià Barrabés, Sílvia Massaguer, Anna Ferri, María José Albiol-Quer, Maite de Llorens, Rafael Peracaula, Rosa |
author_facet | Llop, Esther Guerrero, Pedro E Duran, Adrià Barrabés, Sílvia Massaguer, Anna Ferri, María José Albiol-Quer, Maite de Llorens, Rafael Peracaula, Rosa |
author_sort | Llop, Esther |
collection | PubMed |
description | Pancreatic cancer (PaC) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. |
format | Online Article Text |
id | pubmed-6021768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-60217682018-06-29 Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma Llop, Esther Guerrero, Pedro E Duran, Adrià Barrabés, Sílvia Massaguer, Anna Ferri, María José Albiol-Quer, Maite de Llorens, Rafael Peracaula, Rosa World J Gastroenterol Review Pancreatic cancer (PaC) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. Baishideng Publishing Group Inc 2018-06-28 2018-06-28 /pmc/articles/PMC6021768/ /pubmed/29962812 http://dx.doi.org/10.3748/wjg.v24.i24.2537 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Llop, Esther Guerrero, Pedro E Duran, Adrià Barrabés, Sílvia Massaguer, Anna Ferri, María José Albiol-Quer, Maite de Llorens, Rafael Peracaula, Rosa Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
title | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
title_full | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
title_fullStr | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
title_full_unstemmed | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
title_short | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
title_sort | glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021768/ https://www.ncbi.nlm.nih.gov/pubmed/29962812 http://dx.doi.org/10.3748/wjg.v24.i24.2537 |
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