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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022321/ https://www.ncbi.nlm.nih.gov/pubmed/30013600 http://dx.doi.org/10.1155/2018/3057624 |
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author | Wang, Mengyuan Yuan, Quan Xie, Liang |
author_facet | Wang, Mengyuan Yuan, Quan Xie, Liang |
author_sort | Wang, Mengyuan |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation. |
format | Online Article Text |
id | pubmed-6022321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60223212018-07-16 Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application Wang, Mengyuan Yuan, Quan Xie, Liang Stem Cells Int Review Article Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation. Hindawi 2018-06-14 /pmc/articles/PMC6022321/ /pubmed/30013600 http://dx.doi.org/10.1155/2018/3057624 Text en Copyright © 2018 Mengyuan Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Mengyuan Yuan, Quan Xie, Liang Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
title | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
title_full | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
title_fullStr | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
title_full_unstemmed | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
title_short | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
title_sort | mesenchymal stem cell-based immunomodulation: properties and clinical application |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022321/ https://www.ncbi.nlm.nih.gov/pubmed/30013600 http://dx.doi.org/10.1155/2018/3057624 |
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