Cargando…

The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases

Orphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan receptor (NR4A) superfamily that has sparked interest across different research fields in recent years. Several studies have demonstrated that ligand-independent NR4A1 is an immediate-early response gene and the pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lei, Wang, Qun, Liu, Wen, Liu, Fangyan, Ji, Ailing, Li, Yanzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022324/ https://www.ncbi.nlm.nih.gov/pubmed/30013988 http://dx.doi.org/10.1155/2018/9363461

Ejemplares similares

New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy
por: Zhang, Lei, et al.
Publicado: (2018)

Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer
por: Garattini, Enrico, et al.
Publicado: (2016)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020)

Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer
por: Aesoy, Reidun, et al.
Publicado: (2015)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2005)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2018)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2019)

In Silico Adoption of an Orphan Nuclear Receptor NR4A1
por: Lanig, Harald, et al.
Publicado: (2015)

New Insights into Orphan Nuclear Receptor SHP in Liver Cancer
por: Zou, An, et al.
Publicado: (2015)

Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)
por: Zhang, Lei, et al.
Publicado: (2023)

Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases
por: Chen, Yun, et al.
Publicado: (2023)

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
por: Odagiu, Livia, et al.
Publicado: (2021)

Advancements in therapeutically targeting orphan GPCRs
por: Stockert, Jennifer A., et al.
Publicado: (2015)

The role of the orphan nuclear receptor COUP-TFII in tumorigenesis
por: Xu, Mafei, et al.
Publicado: (2015)

Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2
por: FANG, FANG, et al.
Publicado: (2012)

Orphan Nuclear Receptor Nur77 Regulates Androgen Receptor Gene Expression in Mouse Ovary
por: Dai, Anyi, et al.
Publicado: (2012)

A chemogenomics based approach for deorphanization of testicular receptor 4: An orphan receptor of nuclear receptor superfamily
por: Deshmukh, Savita, et al.
Publicado: (2013)

The orphan Rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation?
por: Ramakrishnan, Sathiya N., et al.
Publicado: (2006)

Structural basis for corepressor assembly by the orphan nuclear receptor TLX
por: Zhi, Xiaoyong, et al.
Publicado: (2015)

Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ
por: Lee, Ja Hee, et al.
Publicado: (2012)

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment
por: Wang, Leiming, et al.
Publicado: (2020)

Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma
por: Li, Xudan, et al.
Publicado: (2022)

Orphan receptors.
Publicado: (1993)

A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways
por: Garruti, Gabriella, et al.
Publicado: (2012)

Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia
por: Pan, Pan, et al.
Publicado: (2020)

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii
por: Beiting, Daniel P., et al.
Publicado: (2015)

Therapeutic Opportunities and Challenges in Targeting the Orphan G Protein-Coupled Receptor GPR35
por: Quon, Tezz, et al.
Publicado: (2020)

Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor
por: Yuan, Xiaohui, et al.
Publicado: (2009)

Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer
por: Llopis, Shawn, et al.
Publicado: (2013)

Orphan nuclear receptor TLX regulates astrogenesis by modulating BMP signaling
por: Qin, Song, et al.
Publicado: (2014)

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene
por: Fugazza, Cristina, et al.
Publicado: (2020)

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)
por: Lee, Miok, et al.
Publicado: (2023)

The Oncoprotein BCL11A Binds to Orphan Nuclear Receptor TLX and Potentiates its Transrepressive Function
por: Estruch, Sara B., et al.
Publicado: (2012)

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor
por: Kruse, Schoen W, et al.
Publicado: (2008)

Involvement of the orphan nuclear estrogen receptor-related receptor α in osteoclast adhesion and transmigration
por: Bonnelye, Edith, et al.
Publicado: (2010)

Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
por: McCoy, Joseph M, et al.
Publicado: (2015)

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues
por: Herring, Jacob A., et al.
Publicado: (2019)

Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression
por: Kim, Don-Kyu, et al.
Publicado: (2016)

miR-34a Inhibits Proliferation and Invasion of Bladder Cancer Cells by Targeting Orphan Nuclear Receptor HNF4G
por: Sun, Huaibin, et al.
Publicado: (2015)

Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain
por: Tseng, Hsiao-Chun, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ckrj2olahg8r9b53uo8galo77s