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Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage

BACKGROUND: Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary immune response. The objective of the study was to investigate whether brain...

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Autores principales: Hegen, Harald, Helbok, Raimund, Kofler, Mario, Pfausler, Bettina, Schiefecker, Alois, Schmutzhard, Erich, Beer, Ronny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022437/
https://www.ncbi.nlm.nih.gov/pubmed/29954343
http://dx.doi.org/10.1186/s12883-018-1097-1
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author Hegen, Harald
Helbok, Raimund
Kofler, Mario
Pfausler, Bettina
Schiefecker, Alois
Schmutzhard, Erich
Beer, Ronny
author_facet Hegen, Harald
Helbok, Raimund
Kofler, Mario
Pfausler, Bettina
Schiefecker, Alois
Schmutzhard, Erich
Beer, Ronny
author_sort Hegen, Harald
collection PubMed
description BACKGROUND: Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary immune response. The objective of the study was to investigate whether brain damage due to spontaneous subarachnoid haemorrhage (SAH) or intracerebral haemorrhage (ICH) induces reactivity against neuronal surface proteins. METHODS: Patients with spontaneous SAH and ICH, who had cerebrospinal fluid (CSF) and serum sampling within 2 weeks after disease onset (baseline) and afterwards at least 10 days later (follow-up), were included. Antibodies against NMDA, GABA-B, AMPA-1/− 2 receptor, LGI1 and CASPR2 were determined by indirect immunofluorescence. RESULTS: A total of 43 SAH and 11 ICH patients aged 62 (±12) years (65% females) had simultaneous CSF/ serum sampling median 5 and 26.5 days after disease onset. At baseline, all CSF samples were collected via ventricular drainage, at follow-up 20 (37.0%) patients had CSF collection by lumbar puncture because ventricular drain had been already removed. All CSF and serum samples at baseline and follow-up tested negative for antibodies against NMDA, GABA-B, AMPA-1/− 2 receptor, LGI1 and CASPR2. CONCLUSIONS: Immunoreactivity against common neuronal surface proteins was not observed within the early disease course of spontaneous SAH and ICH.
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spelling pubmed-60224372018-07-09 Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage Hegen, Harald Helbok, Raimund Kofler, Mario Pfausler, Bettina Schiefecker, Alois Schmutzhard, Erich Beer, Ronny BMC Neurol Research Article BACKGROUND: Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary immune response. The objective of the study was to investigate whether brain damage due to spontaneous subarachnoid haemorrhage (SAH) or intracerebral haemorrhage (ICH) induces reactivity against neuronal surface proteins. METHODS: Patients with spontaneous SAH and ICH, who had cerebrospinal fluid (CSF) and serum sampling within 2 weeks after disease onset (baseline) and afterwards at least 10 days later (follow-up), were included. Antibodies against NMDA, GABA-B, AMPA-1/− 2 receptor, LGI1 and CASPR2 were determined by indirect immunofluorescence. RESULTS: A total of 43 SAH and 11 ICH patients aged 62 (±12) years (65% females) had simultaneous CSF/ serum sampling median 5 and 26.5 days after disease onset. At baseline, all CSF samples were collected via ventricular drainage, at follow-up 20 (37.0%) patients had CSF collection by lumbar puncture because ventricular drain had been already removed. All CSF and serum samples at baseline and follow-up tested negative for antibodies against NMDA, GABA-B, AMPA-1/− 2 receptor, LGI1 and CASPR2. CONCLUSIONS: Immunoreactivity against common neuronal surface proteins was not observed within the early disease course of spontaneous SAH and ICH. BioMed Central 2018-06-28 /pmc/articles/PMC6022437/ /pubmed/29954343 http://dx.doi.org/10.1186/s12883-018-1097-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hegen, Harald
Helbok, Raimund
Kofler, Mario
Pfausler, Bettina
Schiefecker, Alois
Schmutzhard, Erich
Beer, Ronny
Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
title Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
title_full Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
title_fullStr Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
title_full_unstemmed Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
title_short Autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
title_sort autoantibodies against neuronal surface proteins in spontaneous subarachnoid and intracerebral haemorrhage
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022437/
https://www.ncbi.nlm.nih.gov/pubmed/29954343
http://dx.doi.org/10.1186/s12883-018-1097-1
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