Plasmablastic lymphoma in Malawi

Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, an...

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Detalles Bibliográficos
Autores principales: Zuze, Takondwa, Painschab, Matthew S., Seguin, Ryan, Kudowa, Evarista, Kaimila, Bongani, Kasonkanji, Edwards, Tomoka, Tamiwe, Dhungel, Bal Mukunda, Mulenga, Maurice, Chikasema, Maria, Tewete, Blessings, Ntangwanika, Asekanadziwa, Chiyoyola, Sarah, Chimzimu, Fred, Kampani, Coxcilly, Krysiak, Robert, Montgomery, Nathan D., Fedoriw, Yuri, Gopal, Satish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022505/
https://www.ncbi.nlm.nih.gov/pubmed/29988350
http://dx.doi.org/10.1186/s13027-018-0195-4
Descripción
Sumario:Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24–79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA.

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