Plasmablastic lymphoma in Malawi

Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, an...

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Autores principales: Zuze, Takondwa, Painschab, Matthew S., Seguin, Ryan, Kudowa, Evarista, Kaimila, Bongani, Kasonkanji, Edwards, Tomoka, Tamiwe, Dhungel, Bal Mukunda, Mulenga, Maurice, Chikasema, Maria, Tewete, Blessings, Ntangwanika, Asekanadziwa, Chiyoyola, Sarah, Chimzimu, Fred, Kampani, Coxcilly, Krysiak, Robert, Montgomery, Nathan D., Fedoriw, Yuri, Gopal, Satish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022505/
https://www.ncbi.nlm.nih.gov/pubmed/29988350
http://dx.doi.org/10.1186/s13027-018-0195-4
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author Zuze, Takondwa
Painschab, Matthew S.
Seguin, Ryan
Kudowa, Evarista
Kaimila, Bongani
Kasonkanji, Edwards
Tomoka, Tamiwe
Dhungel, Bal Mukunda
Mulenga, Maurice
Chikasema, Maria
Tewete, Blessings
Ntangwanika, Asekanadziwa
Chiyoyola, Sarah
Chimzimu, Fred
Kampani, Coxcilly
Krysiak, Robert
Montgomery, Nathan D.
Fedoriw, Yuri
Gopal, Satish
author_facet Zuze, Takondwa
Painschab, Matthew S.
Seguin, Ryan
Kudowa, Evarista
Kaimila, Bongani
Kasonkanji, Edwards
Tomoka, Tamiwe
Dhungel, Bal Mukunda
Mulenga, Maurice
Chikasema, Maria
Tewete, Blessings
Ntangwanika, Asekanadziwa
Chiyoyola, Sarah
Chimzimu, Fred
Kampani, Coxcilly
Krysiak, Robert
Montgomery, Nathan D.
Fedoriw, Yuri
Gopal, Satish
author_sort Zuze, Takondwa
collection PubMed
description Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24–79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA.
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spelling pubmed-60225052018-07-09 Plasmablastic lymphoma in Malawi Zuze, Takondwa Painschab, Matthew S. Seguin, Ryan Kudowa, Evarista Kaimila, Bongani Kasonkanji, Edwards Tomoka, Tamiwe Dhungel, Bal Mukunda Mulenga, Maurice Chikasema, Maria Tewete, Blessings Ntangwanika, Asekanadziwa Chiyoyola, Sarah Chimzimu, Fred Kampani, Coxcilly Krysiak, Robert Montgomery, Nathan D. Fedoriw, Yuri Gopal, Satish Infect Agent Cancer Short Report Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24–79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA. BioMed Central 2018-06-28 /pmc/articles/PMC6022505/ /pubmed/29988350 http://dx.doi.org/10.1186/s13027-018-0195-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Zuze, Takondwa
Painschab, Matthew S.
Seguin, Ryan
Kudowa, Evarista
Kaimila, Bongani
Kasonkanji, Edwards
Tomoka, Tamiwe
Dhungel, Bal Mukunda
Mulenga, Maurice
Chikasema, Maria
Tewete, Blessings
Ntangwanika, Asekanadziwa
Chiyoyola, Sarah
Chimzimu, Fred
Kampani, Coxcilly
Krysiak, Robert
Montgomery, Nathan D.
Fedoriw, Yuri
Gopal, Satish
Plasmablastic lymphoma in Malawi
title Plasmablastic lymphoma in Malawi
title_full Plasmablastic lymphoma in Malawi
title_fullStr Plasmablastic lymphoma in Malawi
title_full_unstemmed Plasmablastic lymphoma in Malawi
title_short Plasmablastic lymphoma in Malawi
title_sort plasmablastic lymphoma in malawi
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022505/
https://www.ncbi.nlm.nih.gov/pubmed/29988350
http://dx.doi.org/10.1186/s13027-018-0195-4
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