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Optimization and profile calculation of ODE models using second order adjoint sensitivity analysis

MOTIVATION: Parameter estimation methods for ordinary differential equation (ODE) models of biological processes can exploit gradients and Hessians of objective functions to achieve convergence and computational efficiency. However, the computational complexity of established methods to evaluate the...

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Detalles Bibliográficos
Autores principales:	Stapor, Paul, Fröhlich, Fabian, Hasenauer, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Ismb 2018–Intelligent Systems for Molecular Biology Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022646/ https://www.ncbi.nlm.nih.gov/pubmed/29949990 http://dx.doi.org/10.1093/bioinformatics/bty230

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