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DisruPPI: structure-based computational redesign algorithm for protein binding disruption
MOTIVATION: Disruption of protein–protein interactions can mitigate antibody recognition of therapeutic proteins, yield monomeric forms of oligomeric proteins, and elucidate signaling mechanisms, among other applications. While designing affinity-enhancing mutations remains generally quite challengi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022686/ https://www.ncbi.nlm.nih.gov/pubmed/29949961 http://dx.doi.org/10.1093/bioinformatics/bty274 |