Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

OBJECTIVE: Our aim was to identify natural products with anti-tubercular activity. RESULTS: A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identifie...

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Autores principales: Singh, Sheo B., Odingo, Joshua, Bailey, Mai A., Sunde, Bjorn, Korkegian, Aaron, O’Malley, Theresa, Ovechkina, Yulia, Ioerger, Thomas R., Sacchettini, James C., Young, Katherine, Olsen, David B., Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022709/
https://www.ncbi.nlm.nih.gov/pubmed/29954459
http://dx.doi.org/10.1186/s13104-018-3526-z
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author Singh, Sheo B.
Odingo, Joshua
Bailey, Mai A.
Sunde, Bjorn
Korkegian, Aaron
O’Malley, Theresa
Ovechkina, Yulia
Ioerger, Thomas R.
Sacchettini, James C.
Young, Katherine
Olsen, David B.
Parish, Tanya
author_facet Singh, Sheo B.
Odingo, Joshua
Bailey, Mai A.
Sunde, Bjorn
Korkegian, Aaron
O’Malley, Theresa
Ovechkina, Yulia
Ioerger, Thomas R.
Sacchettini, James C.
Young, Katherine
Olsen, David B.
Parish, Tanya
author_sort Singh, Sheo B.
collection PubMed
description OBJECTIVE: Our aim was to identify natural products with anti-tubercular activity. RESULTS: A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3 to 8.9 μM. Eleven structural analogs had no significant activity (MIC > 20 μM) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype.
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spelling pubmed-60227092018-07-09 Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis Singh, Sheo B. Odingo, Joshua Bailey, Mai A. Sunde, Bjorn Korkegian, Aaron O’Malley, Theresa Ovechkina, Yulia Ioerger, Thomas R. Sacchettini, James C. Young, Katherine Olsen, David B. Parish, Tanya BMC Res Notes Research Note OBJECTIVE: Our aim was to identify natural products with anti-tubercular activity. RESULTS: A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3 to 8.9 μM. Eleven structural analogs had no significant activity (MIC > 20 μM) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype. BioMed Central 2018-06-28 /pmc/articles/PMC6022709/ /pubmed/29954459 http://dx.doi.org/10.1186/s13104-018-3526-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Singh, Sheo B.
Odingo, Joshua
Bailey, Mai A.
Sunde, Bjorn
Korkegian, Aaron
O’Malley, Theresa
Ovechkina, Yulia
Ioerger, Thomas R.
Sacchettini, James C.
Young, Katherine
Olsen, David B.
Parish, Tanya
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
title Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
title_full Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
title_fullStr Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
title_full_unstemmed Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
title_short Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
title_sort identification of cyclic hexapeptides natural products with inhibitory potency against mycobacterium tuberculosis
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022709/
https://www.ncbi.nlm.nih.gov/pubmed/29954459
http://dx.doi.org/10.1186/s13104-018-3526-z
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