Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. We show that transcription factors (TFs) occupy multiple loci of individual complex genetic disorders using novel computational methods. Application to 213 phe...

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Detalles Bibliográficos
Autores principales: Harley, John B., Chen, Xiaoting, Pujato, Mario, Miller, Daniel, Maddox, Avery, Forney, Carmy, Magnusen, Albert F., Lynch, Arthur, Chetal, Kashish, Yukawa, Masashi, Barski, Artem, Salomonis, Nathan, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022759/
https://www.ncbi.nlm.nih.gov/pubmed/29662164
http://dx.doi.org/10.1038/s41588-018-0102-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022759/
https://www.ncbi.nlm.nih.gov/pubmed/29662164
http://dx.doi.org/10.1038/s41588-018-0102-3

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