Cargando…

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. We show that transcription factors (TFs) occupy multiple loci of individual complex genetic disorders using novel computational methods. Application to 213 phe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harley, John B., Chen, Xiaoting, Pujato, Mario, Miller, Daniel, Maddox, Avery, Forney, Carmy, Magnusen, Albert F., Lynch, Arthur, Chetal, Kashish, Yukawa, Masashi, Barski, Artem, Salomonis, Nathan, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022759/ https://www.ncbi.nlm.nih.gov/pubmed/29662164 http://dx.doi.org/10.1038/s41588-018-0102-3

Ejemplares similares

Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci
por: Hong, Ted, et al.
Publicado: (2021)

Global discovery of lupus genetic risk variant allelic enhancer activity
por: Lu, Xiaoming, et al.
Publicado: (2021)

Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
por: Petrany, Michael J., et al.
Publicado: (2020)

AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation
por: Yukawa, Masashi, et al.
Publicado: (2019)

Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis
por: Eapen, Amy A., et al.
Publicado: (2022)

Comprehensive Review of Steroid-Sensitive Nephrotic Syndrome Genetic Risk Loci and Transcriptional Regulation as a Possible Mechanistic Link to Disease Risk
por: Stone, Hillarey K., et al.
Publicado: (2020)

A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth
por: Wang, Li, et al.
Publicado: (2023)

Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14
por: Miller, Daniel E., et al.
Publicado: (2019)

A High Prevalence of Anti-EBNA1 Heteroantibodies in Systemic Lupus Erythematosus (SLE) Supports Anti-EBNA1 as an Origin for SLE Autoantibodies
por: Laurynenka, Viktoryia, et al.
Publicado: (2022)

Resolving single-cell heterogeneity from hundreds of thousands of cells through sequential hybrid clustering and NMF
por: Venkatasubramanian, Meenakshi, et al.
Publicado: (2020)

Protocol for Identification and Removal of Doublets with DoubletDecon
por: DePasquale, Erica A.K., et al.
Publicado: (2020)

Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition
por: Maezawa, So, et al.
Publicado: (2020)

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets
por: Hass, Matthew R., et al.
Publicado: (2021)

The Human Cell Atlas bone marrow single-cell interactive web portal
por: Hay, Stuart B., et al.
Publicado: (2018)

Frontotemporal degeneration genetic risk loci and transcription regulation as a possible mechanistic link to disease risk
por: Sawyer, Russell P., et al.
Publicado: (2022)

4277 Functional consequences of the juvenile idiopathic arthritis risk variant at 1q24.3
por: Moncrieffe, Halima, et al.
Publicado: (2020)

Functional Characterization of Human T Cell Hyporesponsiveness Induced by CTLA4-Ig
por: Rochman, Yrina, et al.
Publicado: (2015)

After the Infection: A Survey of Pathogens and Non-communicable Human Disease
por: Lape, Michael, et al.
Publicado: (2023)

Defective transcription elongation in a subset of cancers confers immunotherapy resistance
por: Modur, Vishnu, et al.
Publicado: (2018)

Runx Transcription Factors in T Cells—What Is Beyond Thymic Development?
por: Korinfskaya, Svetlana, et al.
Publicado: (2021)

maxATAC: Genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks
por: Cazares, Tareian A., et al.
Publicado: (2023)

OperomeDB: A Database of Condition-Specific Transcription Units in Prokaryotic Genomes
por: Chetal, Kashish, et al.
Publicado: (2015)

Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis
por: Maezawa, So, et al.
Publicado: (2018)

ERK2 phosphorylation of EBNA1 serine 383 residue is important for EBNA1-dependent transactivation
por: Noh, Ka-Won, et al.
Publicado: (2016)

Mapping an epitope in EBNA‐1 that is recognized by monoclonal antibodies to EBNA‐1 that cross‐react with dsDNA
por: Yadav, Pragya, et al.
Publicado: (2016)

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells
por: Glaser, Laura V., et al.
Publicado: (2017)

Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis
por: Verweyen, Emely L., et al.
Publicado: (2023)

Murine Cytotoxic T Lymphocytes Recognize an Epitope in an EBNA-1 Fragment, but Fail to Lyse EBNA-1–expressing Mouse Cells
por: Mukherjee, Siddhartha, et al.
Publicado: (1998)

A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
por: Wang, Chong, et al.
Publicado: (2023)

The interaction of Epstein-Barr virus encoded transcription factor EBNA2 with multiple sclerosis risk loci is dependent on the risk genotype
por: Keane, Jeremy Thomas, et al.
Publicado: (2021)

The Epstein-Barr Virus EBNA1 Protein
por: Frappier, Lori
Publicado: (2012)

VExD: a curated resource for human gene expression alterations following viral infection
por: Dexheimer, Phillip J, et al.
Publicado: (2023)

The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification
por: Lu, Yi-Chien, et al.
Publicado: (2018)

The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification
por: Lu, Yi-Chien, et al.
Publicado: (2018)

cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes
por: DePasquale, Erica A K, et al.
Publicado: (2019)

Publisher Correction: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
por: Itskovich, Svetlana S., et al.
Publicado: (2020)

MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
por: Itskovich, Svetlana S., et al.
Publicado: (2020)

DNA repair in lupus
por: Xu, Jiadi, et al.
Publicado: (2014)

Gene–environment interactions and their impact on human health
por: Virolainen, Samuel J., et al.
Publicado: (2022)

The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population
por: Namjou, Bahram, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_t6d2p2prl5thpge2hbgp7dgq7g