Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease

OBJECTIVE: This study aimed to assess the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for renal dysfunction in older patients with coronary disease. METHODS: A total of 84 older patients with coronary artery disease were included in this study. Serum NG...

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Autores principales: Zhu, Hong, Qian, Yuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Clinical Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023060/
https://www.ncbi.nlm.nih.gov/pubmed/29595358
http://dx.doi.org/10.1177/0300060517748842
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author Zhu, Hong
Qian, Yuying
author_facet Zhu, Hong
Qian, Yuying
author_sort Zhu, Hong
collection PubMed
description OBJECTIVE: This study aimed to assess the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for renal dysfunction in older patients with coronary disease. METHODS: A total of 84 older patients with coronary artery disease were included in this study. Serum NGAL and cystatin C levels were analysed using commercially available kits. Medical data of all patients were recorded and analysed. RESULTS: NGAL and cystatin C levels were significantly positively correlated with N-terminal prohormone of brain natriuretic peptide levels and negatively correlated with the estimated glomerular filtration rate. The areas under the receiver operating characteristic curves of serum NGAL and cystatin C levels for diagnosing early renal dysfunction were 0.884 and 0.744, respectively. CONCLUSION: Serum NGAL and cystatin C are potential early and sensitive markers of renal dysfunction in older patients with coronary artery disease.
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spelling pubmed-60230602018-07-05 Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease Zhu, Hong Qian, Yuying J Int Med Res Clinical Research Reports OBJECTIVE: This study aimed to assess the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for renal dysfunction in older patients with coronary disease. METHODS: A total of 84 older patients with coronary artery disease were included in this study. Serum NGAL and cystatin C levels were analysed using commercially available kits. Medical data of all patients were recorded and analysed. RESULTS: NGAL and cystatin C levels were significantly positively correlated with N-terminal prohormone of brain natriuretic peptide levels and negatively correlated with the estimated glomerular filtration rate. The areas under the receiver operating characteristic curves of serum NGAL and cystatin C levels for diagnosing early renal dysfunction were 0.884 and 0.744, respectively. CONCLUSION: Serum NGAL and cystatin C are potential early and sensitive markers of renal dysfunction in older patients with coronary artery disease. SAGE Publications 2018-03-29 2018-06 /pmc/articles/PMC6023060/ /pubmed/29595358 http://dx.doi.org/10.1177/0300060517748842 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Zhu, Hong
Qian, Yuying
Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease
title Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease
title_full Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease
title_fullStr Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease
title_full_unstemmed Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease
title_short Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease
title_sort serum neutrophil gelatinase-associated lipocalin and cystatin c are diagnostic markers of renal dysfunction in older patients with coronary artery disease
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023060/
https://www.ncbi.nlm.nih.gov/pubmed/29595358
http://dx.doi.org/10.1177/0300060517748842
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AT qianyuying serumneutrophilgelatinaseassociatedlipocalinandcystatincarediagnosticmarkersofrenaldysfunctioninolderpatientswithcoronaryarterydisease

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