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Contact prediction is hardest for the most informative contacts, but improves with the incorporation of contact potentials
Co-evolution between pairs of residues in a multiple sequence alignment (MSA) of homologous proteins has long been proposed as an indicator of structural contacts. Recently, several methods, such as direct-coupling analysis (DCA) and MetaPSICOV, have been shown to achieve impressive rates of contact...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023208/ https://www.ncbi.nlm.nih.gov/pubmed/29953468 http://dx.doi.org/10.1371/journal.pone.0199585 |