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RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is widely used, it does not efficiently protect against pulmonary tuberculosis and an improved tuberculosis vaccine is therefore urgently needed. Mycobacterium tuberculosis uses different ESX/Type VII secretion (T7S...

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Detalles Bibliográficos
Autores principales:	Ates, Louis S., Sayes, Fadel, Frigui, Wafa, Ummels, Roy, Damen, Merel P. M., Bottai, Daria, Behr, Marcel A., van Heijst, Jeroen W. J., Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023246/ https://www.ncbi.nlm.nih.gov/pubmed/29912964 http://dx.doi.org/10.1371/journal.ppat.1007139

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