Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemolysis and a high risk of thrombosis, that is due to a deficiency in several cell surface proteins that prevent complement activation. Its origin has been traced to a somatic mutation in the PIG-A gene...

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Detalles Bibliográficos
Autores principales: Mon Père, Nathaniel, Lenaerts, Tom, Pacheco, Jorge M., Dingli, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023248/
https://www.ncbi.nlm.nih.gov/pubmed/29912864
http://dx.doi.org/10.1371/journal.pcbi.1006133

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