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Sporotrichin Skin Test for the Diagnosis of Sporotrichosis

Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichi...

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Autores principales: Bonifaz, Alexandro, Toriello, Conchita, Araiza, Javier, Ramírez-Soto, Max C., Tirado-Sánchez, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023300/
https://www.ncbi.nlm.nih.gov/pubmed/29747377
http://dx.doi.org/10.3390/jof4020055
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author Bonifaz, Alexandro
Toriello, Conchita
Araiza, Javier
Ramírez-Soto, Max C.
Tirado-Sánchez, Andrés
author_facet Bonifaz, Alexandro
Toriello, Conchita
Araiza, Javier
Ramírez-Soto, Max C.
Tirado-Sánchez, Andrés
author_sort Bonifaz, Alexandro
collection PubMed
description Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin as a skin test helps us as an auxiliary diagnosis before a positive sample culture.
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spelling pubmed-60233002018-07-05 Sporotrichin Skin Test for the Diagnosis of Sporotrichosis Bonifaz, Alexandro Toriello, Conchita Araiza, Javier Ramírez-Soto, Max C. Tirado-Sánchez, Andrés J Fungi (Basel) Article Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin as a skin test helps us as an auxiliary diagnosis before a positive sample culture. MDPI 2018-05-09 /pmc/articles/PMC6023300/ /pubmed/29747377 http://dx.doi.org/10.3390/jof4020055 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bonifaz, Alexandro
Toriello, Conchita
Araiza, Javier
Ramírez-Soto, Max C.
Tirado-Sánchez, Andrés
Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
title Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
title_full Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
title_fullStr Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
title_full_unstemmed Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
title_short Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
title_sort sporotrichin skin test for the diagnosis of sporotrichosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023300/
https://www.ncbi.nlm.nih.gov/pubmed/29747377
http://dx.doi.org/10.3390/jof4020055
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