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Sporotrichin Skin Test for the Diagnosis of Sporotrichosis
Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023300/ https://www.ncbi.nlm.nih.gov/pubmed/29747377 http://dx.doi.org/10.3390/jof4020055 |
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author | Bonifaz, Alexandro Toriello, Conchita Araiza, Javier Ramírez-Soto, Max C. Tirado-Sánchez, Andrés |
author_facet | Bonifaz, Alexandro Toriello, Conchita Araiza, Javier Ramírez-Soto, Max C. Tirado-Sánchez, Andrés |
author_sort | Bonifaz, Alexandro |
collection | PubMed |
description | Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin as a skin test helps us as an auxiliary diagnosis before a positive sample culture. |
format | Online Article Text |
id | pubmed-6023300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60233002018-07-05 Sporotrichin Skin Test for the Diagnosis of Sporotrichosis Bonifaz, Alexandro Toriello, Conchita Araiza, Javier Ramírez-Soto, Max C. Tirado-Sánchez, Andrés J Fungi (Basel) Article Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin as a skin test helps us as an auxiliary diagnosis before a positive sample culture. MDPI 2018-05-09 /pmc/articles/PMC6023300/ /pubmed/29747377 http://dx.doi.org/10.3390/jof4020055 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bonifaz, Alexandro Toriello, Conchita Araiza, Javier Ramírez-Soto, Max C. Tirado-Sánchez, Andrés Sporotrichin Skin Test for the Diagnosis of Sporotrichosis |
title | Sporotrichin Skin Test for the Diagnosis of Sporotrichosis |
title_full | Sporotrichin Skin Test for the Diagnosis of Sporotrichosis |
title_fullStr | Sporotrichin Skin Test for the Diagnosis of Sporotrichosis |
title_full_unstemmed | Sporotrichin Skin Test for the Diagnosis of Sporotrichosis |
title_short | Sporotrichin Skin Test for the Diagnosis of Sporotrichosis |
title_sort | sporotrichin skin test for the diagnosis of sporotrichosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023300/ https://www.ncbi.nlm.nih.gov/pubmed/29747377 http://dx.doi.org/10.3390/jof4020055 |
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