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Viral Vectors in Gene Therapy
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment o...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023384/ https://www.ncbi.nlm.nih.gov/pubmed/29883422 http://dx.doi.org/10.3390/diseases6020042 |
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author | Lundstrom, Kenneth |
author_facet | Lundstrom, Kenneth |
author_sort | Lundstrom, Kenneth |
collection | PubMed |
description | Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment of various diseases such as metabolic, cardiovascular, muscular, hematologic, ophthalmologic, and infectious diseases and different types of cancer. Recent development in the area of immunotherapy has provided both preventive and therapeutic approaches. Furthermore, gene silencing generating a reversible effect has become an interesting alternative, and is well-suited for delivery by viral vectors. A number of preclinical studies have demonstrated therapeutic and prophylactic efficacy in animal models and furthermore in clinical trials. Several viral vector-based drugs have also been globally approved. |
format | Online Article Text |
id | pubmed-6023384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60233842018-07-03 Viral Vectors in Gene Therapy Lundstrom, Kenneth Diseases Review Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment of various diseases such as metabolic, cardiovascular, muscular, hematologic, ophthalmologic, and infectious diseases and different types of cancer. Recent development in the area of immunotherapy has provided both preventive and therapeutic approaches. Furthermore, gene silencing generating a reversible effect has become an interesting alternative, and is well-suited for delivery by viral vectors. A number of preclinical studies have demonstrated therapeutic and prophylactic efficacy in animal models and furthermore in clinical trials. Several viral vector-based drugs have also been globally approved. MDPI 2018-05-21 /pmc/articles/PMC6023384/ /pubmed/29883422 http://dx.doi.org/10.3390/diseases6020042 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lundstrom, Kenneth Viral Vectors in Gene Therapy |
title | Viral Vectors in Gene Therapy |
title_full | Viral Vectors in Gene Therapy |
title_fullStr | Viral Vectors in Gene Therapy |
title_full_unstemmed | Viral Vectors in Gene Therapy |
title_short | Viral Vectors in Gene Therapy |
title_sort | viral vectors in gene therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023384/ https://www.ncbi.nlm.nih.gov/pubmed/29883422 http://dx.doi.org/10.3390/diseases6020042 |
work_keys_str_mv | AT lundstromkenneth viralvectorsingenetherapy |