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Lipid Biosynthesis as an Antifungal Target

Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and triacylglycerols (TAGs), are important biomolecules for the viability of all cells. Phospholipids, sphingolipids, and sterols are important constituents of biological membranes. Many lipids play important roles in the...

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Detalles Bibliográficos
Autores principales: Pan, Jiao, Hu, Cuiting, Yu, Jae-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023442/
https://www.ncbi.nlm.nih.gov/pubmed/29677130
http://dx.doi.org/10.3390/jof4020050
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author Pan, Jiao
Hu, Cuiting
Yu, Jae-Hyuk
author_facet Pan, Jiao
Hu, Cuiting
Yu, Jae-Hyuk
author_sort Pan, Jiao
collection PubMed
description Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and triacylglycerols (TAGs), are important biomolecules for the viability of all cells. Phospholipids, sphingolipids, and sterols are important constituents of biological membranes. Many lipids play important roles in the regulation of cell metabolism by acting as signaling molecules. Neutral lipids, including TAGs and sterol esters (STEs), are important storage lipids in cells. In view of the importance of lipid molecules, this review briefly summarizes the metabolic pathways for sterols, phospholipids, sphingolipids, fatty acids, and neutral lipids in fungi and illustrates the differences between fungal and human (or other mammalian) cells, especially in relation to lipid biosynthetic pathways. These differences might provide valuable clues for us to find target proteins for novel antifungal drugs. In addition, the development of lipidomics technology in recent years has supplied us with a shortcut for finding new antifungal drug targets; this ability is important for guiding our research on pathogenic fungi.
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spelling pubmed-60234422018-07-05 Lipid Biosynthesis as an Antifungal Target Pan, Jiao Hu, Cuiting Yu, Jae-Hyuk J Fungi (Basel) Review Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and triacylglycerols (TAGs), are important biomolecules for the viability of all cells. Phospholipids, sphingolipids, and sterols are important constituents of biological membranes. Many lipids play important roles in the regulation of cell metabolism by acting as signaling molecules. Neutral lipids, including TAGs and sterol esters (STEs), are important storage lipids in cells. In view of the importance of lipid molecules, this review briefly summarizes the metabolic pathways for sterols, phospholipids, sphingolipids, fatty acids, and neutral lipids in fungi and illustrates the differences between fungal and human (or other mammalian) cells, especially in relation to lipid biosynthetic pathways. These differences might provide valuable clues for us to find target proteins for novel antifungal drugs. In addition, the development of lipidomics technology in recent years has supplied us with a shortcut for finding new antifungal drug targets; this ability is important for guiding our research on pathogenic fungi. MDPI 2018-04-20 /pmc/articles/PMC6023442/ /pubmed/29677130 http://dx.doi.org/10.3390/jof4020050 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pan, Jiao
Hu, Cuiting
Yu, Jae-Hyuk
Lipid Biosynthesis as an Antifungal Target
title Lipid Biosynthesis as an Antifungal Target
title_full Lipid Biosynthesis as an Antifungal Target
title_fullStr Lipid Biosynthesis as an Antifungal Target
title_full_unstemmed Lipid Biosynthesis as an Antifungal Target
title_short Lipid Biosynthesis as an Antifungal Target
title_sort lipid biosynthesis as an antifungal target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023442/
https://www.ncbi.nlm.nih.gov/pubmed/29677130
http://dx.doi.org/10.3390/jof4020050
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