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Microfluidic Devices for Drug Assays

In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter plate, droplets microfluidics as well as continuou...

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Detalles Bibliográficos
Autores principales: Regnault, Clément, Dheeman, Dharmendra S., Hochstetter, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023517/
https://www.ncbi.nlm.nih.gov/pubmed/29925804
http://dx.doi.org/10.3390/ht7020018
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author Regnault, Clément
Dheeman, Dharmendra S.
Hochstetter, Axel
author_facet Regnault, Clément
Dheeman, Dharmendra S.
Hochstetter, Axel
author_sort Regnault, Clément
collection PubMed
description In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter plate, droplets microfluidics as well as continuous flow, diffusion and concentration gradients-based microfluidic drug assays. Therefore, we reviewed over 100 recent publications in the field and sorted them according to their microfluidic approach. As a result, we are showcasing, comparing and discussing broadly applied approaches as well as singular promising ones that might contribute to shaping the future of this field.
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spelling pubmed-60235172018-07-03 Microfluidic Devices for Drug Assays Regnault, Clément Dheeman, Dharmendra S. Hochstetter, Axel High Throughput Review In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter plate, droplets microfluidics as well as continuous flow, diffusion and concentration gradients-based microfluidic drug assays. Therefore, we reviewed over 100 recent publications in the field and sorted them according to their microfluidic approach. As a result, we are showcasing, comparing and discussing broadly applied approaches as well as singular promising ones that might contribute to shaping the future of this field. MDPI 2018-06-20 /pmc/articles/PMC6023517/ /pubmed/29925804 http://dx.doi.org/10.3390/ht7020018 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Regnault, Clément
Dheeman, Dharmendra S.
Hochstetter, Axel
Microfluidic Devices for Drug Assays
title Microfluidic Devices for Drug Assays
title_full Microfluidic Devices for Drug Assays
title_fullStr Microfluidic Devices for Drug Assays
title_full_unstemmed Microfluidic Devices for Drug Assays
title_short Microfluidic Devices for Drug Assays
title_sort microfluidic devices for drug assays
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023517/
https://www.ncbi.nlm.nih.gov/pubmed/29925804
http://dx.doi.org/10.3390/ht7020018
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