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Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects

BACKGROUND: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence of hypertension and resistant hypertension (RHTN) represent a great area of interest for investigation. OBJECTIVE: The purpose of this study was to eval...

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Autores principales: Catharina, Arthur Santa, Modolo, Rodrigo, Ritter, Alessandra Mileni Versuti, Sabbatini, Andréa Rodrigues, Lopes, Heno Ferreira, Moreno Junior, Heitor, de Faria, Ana Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023630/
https://www.ncbi.nlm.nih.gov/pubmed/30226908
http://dx.doi.org/10.5935/abc.20180076
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author Catharina, Arthur Santa
Modolo, Rodrigo
Ritter, Alessandra Mileni Versuti
Sabbatini, Andréa Rodrigues
Lopes, Heno Ferreira
Moreno Junior, Heitor
de Faria, Ana Paula
author_facet Catharina, Arthur Santa
Modolo, Rodrigo
Ritter, Alessandra Mileni Versuti
Sabbatini, Andréa Rodrigues
Lopes, Heno Ferreira
Moreno Junior, Heitor
de Faria, Ana Paula
author_sort Catharina, Arthur Santa
collection PubMed
description BACKGROUND: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence of hypertension and resistant hypertension (RHTN) represent a great area of interest for investigation. OBJECTIVE: The purpose of this study was to evaluate the prevalence of MetS and the clinical features associated with it in resistant and mild to moderate hypertensives. METHODS: This cross-sectional study included 236 patients, (i) 129 mild to moderate hypertensive patients and (ii) 107 patients with RHTN. We measured blood pressure (BP) and adipokines levels, and performed bioelectrical impedance analysis. Microalbuminuria (MA), cardiac hypertrophy and arterial stiffness were also assessed. The significance level of alpha = 0.05 was adopted. RESULTS: We found a MetS prevalence of 73% in resistant and 60% in mild-to-moderate hypertensive patients. In a multiple regression analysis, MA (odds ratio = 8.51; p = 0.01), leptin/adiponectin ratio (LAR) (odds ratio = 4.13; p = 0.01) and RHTN (odds ratio = 3.75; p = 0.03) were independently associated with the presence of MetS apart from potential confounders. CONCLUSIONS: Our findings suggest that both resistant and controlled hypertensive subjects have a high prevalence of MetS. In addition, MetS-related metabolic derangements may cause early renal and hormonal changes. Finally, LAR may be useful as a reliable biomarker for identifying those hypertensive subjects who are at risk for developing MetS.
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spelling pubmed-60236302018-07-06 Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects Catharina, Arthur Santa Modolo, Rodrigo Ritter, Alessandra Mileni Versuti Sabbatini, Andréa Rodrigues Lopes, Heno Ferreira Moreno Junior, Heitor de Faria, Ana Paula Arq Bras Cardiol Original Article BACKGROUND: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence of hypertension and resistant hypertension (RHTN) represent a great area of interest for investigation. OBJECTIVE: The purpose of this study was to evaluate the prevalence of MetS and the clinical features associated with it in resistant and mild to moderate hypertensives. METHODS: This cross-sectional study included 236 patients, (i) 129 mild to moderate hypertensive patients and (ii) 107 patients with RHTN. We measured blood pressure (BP) and adipokines levels, and performed bioelectrical impedance analysis. Microalbuminuria (MA), cardiac hypertrophy and arterial stiffness were also assessed. The significance level of alpha = 0.05 was adopted. RESULTS: We found a MetS prevalence of 73% in resistant and 60% in mild-to-moderate hypertensive patients. In a multiple regression analysis, MA (odds ratio = 8.51; p = 0.01), leptin/adiponectin ratio (LAR) (odds ratio = 4.13; p = 0.01) and RHTN (odds ratio = 3.75; p = 0.03) were independently associated with the presence of MetS apart from potential confounders. CONCLUSIONS: Our findings suggest that both resistant and controlled hypertensive subjects have a high prevalence of MetS. In addition, MetS-related metabolic derangements may cause early renal and hormonal changes. Finally, LAR may be useful as a reliable biomarker for identifying those hypertensive subjects who are at risk for developing MetS. Sociedade Brasileira de Cardiologia - SBC 2018-07 /pmc/articles/PMC6023630/ /pubmed/30226908 http://dx.doi.org/10.5935/abc.20180076 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Catharina, Arthur Santa
Modolo, Rodrigo
Ritter, Alessandra Mileni Versuti
Sabbatini, Andréa Rodrigues
Lopes, Heno Ferreira
Moreno Junior, Heitor
de Faria, Ana Paula
Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects
title Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects
title_full Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects
title_fullStr Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects
title_full_unstemmed Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects
title_short Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects
title_sort metabolic syndrome-related features in controlled and resistant hypertensive subjects
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023630/
https://www.ncbi.nlm.nih.gov/pubmed/30226908
http://dx.doi.org/10.5935/abc.20180076
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