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Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

OBJECTIVE—: Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites. The difference in PAR4 signaling by race is partially explained by a single-nucleotide variant in PAR4 encoding for either an alanine or th...

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Detalles Bibliográficos
Autores principales:	Tourdot, Benjamin E., Stoveken, Hannah, Trumbo, Derek, Yeung, Jennifer, Kanthi, Yogendra, Edelstein, Leonard C., Bray, Paul F., Tall, Gregory G., Holinstat, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Translational Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023764/ https://www.ncbi.nlm.nih.gov/pubmed/29748334 http://dx.doi.org/10.1161/ATVBAHA.118.311112

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