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One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors

High-capacity adenoviral vectors (HCAdVs) devoid of all coding genes are powerful tools to deliver large DNA cargos into cells. Here HCAdVs were designed to deliver a multiplexed complete CRISPR/Cas9 nuclease system or a complete pair of transcription activator-like effector nucleases (TALENs) direc...

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Detalles Bibliográficos
Autores principales:	Schiwon, Maren, Ehrke-Schulz, Eric, Oswald, Andreas, Bergmann, Thorsten, Michler, Thomas, Protzer, Ulrike, Ehrhardt, Anja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023846/ https://www.ncbi.nlm.nih.gov/pubmed/30195763 http://dx.doi.org/10.1016/j.omtn.2018.05.006

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