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Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study

Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools. Our aim was to identify whether circulating miRNAs, added to clinical and biochemical markers, yielded better pot...

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Autores principales: Jiménez-Lucena, Rosa, Rangel-Zúñiga, Oriol Alberto, Alcalá-Díaz, Juan Francisco, López-Moreno, Javier, Roncero-Ramos, Irene, Molina-Abril, Helena, Yubero-Serrano, Elena Maria, Caballero-Villarraso, Javier, Delgado-Lista, Javier, Castaño, Justo Pastor, Ordovás, Jose Maria, Pérez-Martinez, Pablo, Camargo, Antonio, López-Miranda, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023857/
https://www.ncbi.nlm.nih.gov/pubmed/30195754
http://dx.doi.org/10.1016/j.omtn.2018.05.002
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author Jiménez-Lucena, Rosa
Rangel-Zúñiga, Oriol Alberto
Alcalá-Díaz, Juan Francisco
López-Moreno, Javier
Roncero-Ramos, Irene
Molina-Abril, Helena
Yubero-Serrano, Elena Maria
Caballero-Villarraso, Javier
Delgado-Lista, Javier
Castaño, Justo Pastor
Ordovás, Jose Maria
Pérez-Martinez, Pablo
Camargo, Antonio
López-Miranda, José
author_facet Jiménez-Lucena, Rosa
Rangel-Zúñiga, Oriol Alberto
Alcalá-Díaz, Juan Francisco
López-Moreno, Javier
Roncero-Ramos, Irene
Molina-Abril, Helena
Yubero-Serrano, Elena Maria
Caballero-Villarraso, Javier
Delgado-Lista, Javier
Castaño, Justo Pastor
Ordovás, Jose Maria
Pérez-Martinez, Pablo
Camargo, Antonio
López-Miranda, José
author_sort Jiménez-Lucena, Rosa
collection PubMed
description Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools. Our aim was to identify whether circulating miRNAs, added to clinical and biochemical markers, yielded better potential for predicting type 2 diabetes. The study included 462 non-diabetic patients at baseline in the CORDIOPREV study. After a median follow-up of 60 months, 107 of them developed type 2 diabetes. Plasma levels of 24 miRNAs were measured at baseline by qRT-PCR, and other strong biomarkers to predict diabetes were determined. The ROC analysis identified 9 miRNAs, which, added to HbA1c, have a greater predictive value in early diagnosis of type 2 diabetes (AUC = 0.8342) than HbA1c alone (AUC = 0.6950). The miRNA and HbA1c-based model did not improve when the FINDRISC was included (AUC = 0.8293). Cox regression analyses showed that patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease (HR = 11.27; 95% CI = 2.61–48.65). Our results suggest that circulating miRNAs could potentially be used as a new tool for predicting the development of type 2 diabetes in clinical practice.
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spelling pubmed-60238572018-06-29 Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study Jiménez-Lucena, Rosa Rangel-Zúñiga, Oriol Alberto Alcalá-Díaz, Juan Francisco López-Moreno, Javier Roncero-Ramos, Irene Molina-Abril, Helena Yubero-Serrano, Elena Maria Caballero-Villarraso, Javier Delgado-Lista, Javier Castaño, Justo Pastor Ordovás, Jose Maria Pérez-Martinez, Pablo Camargo, Antonio López-Miranda, José Mol Ther Nucleic Acids Article Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools. Our aim was to identify whether circulating miRNAs, added to clinical and biochemical markers, yielded better potential for predicting type 2 diabetes. The study included 462 non-diabetic patients at baseline in the CORDIOPREV study. After a median follow-up of 60 months, 107 of them developed type 2 diabetes. Plasma levels of 24 miRNAs were measured at baseline by qRT-PCR, and other strong biomarkers to predict diabetes were determined. The ROC analysis identified 9 miRNAs, which, added to HbA1c, have a greater predictive value in early diagnosis of type 2 diabetes (AUC = 0.8342) than HbA1c alone (AUC = 0.6950). The miRNA and HbA1c-based model did not improve when the FINDRISC was included (AUC = 0.8293). Cox regression analyses showed that patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease (HR = 11.27; 95% CI = 2.61–48.65). Our results suggest that circulating miRNAs could potentially be used as a new tool for predicting the development of type 2 diabetes in clinical practice. American Society of Gene & Cell Therapy 2018-05-08 /pmc/articles/PMC6023857/ /pubmed/30195754 http://dx.doi.org/10.1016/j.omtn.2018.05.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jiménez-Lucena, Rosa
Rangel-Zúñiga, Oriol Alberto
Alcalá-Díaz, Juan Francisco
López-Moreno, Javier
Roncero-Ramos, Irene
Molina-Abril, Helena
Yubero-Serrano, Elena Maria
Caballero-Villarraso, Javier
Delgado-Lista, Javier
Castaño, Justo Pastor
Ordovás, Jose Maria
Pérez-Martinez, Pablo
Camargo, Antonio
López-Miranda, José
Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study
title Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study
title_full Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study
title_fullStr Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study
title_full_unstemmed Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study
title_short Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study
title_sort circulating mirnas as predictive biomarkers of type 2 diabetes mellitus development in coronary heart disease patients from the cordioprev study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023857/
https://www.ncbi.nlm.nih.gov/pubmed/30195754
http://dx.doi.org/10.1016/j.omtn.2018.05.002
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