7B2 chaperone knockout in APP model mice results in reduced plaque burden

Impairment of neuronal proteostasis is a hallmark of Alzheimer’s and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this process, are poorly understood. We have previously shown...

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Detalles Bibliográficos
Autores principales: Jarvela, Timothy S., Womack, Tasha, Georgiou, Polymnia, Gould, Todd D., Eriksen, Jason L., Lindberg, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023903/
https://www.ncbi.nlm.nih.gov/pubmed/29955078
http://dx.doi.org/10.1038/s41598-018-28031-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023903/
https://www.ncbi.nlm.nih.gov/pubmed/29955078
http://dx.doi.org/10.1038/s41598-018-28031-7

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