High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2

Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity. MicroRNAs (miRNAs) are short non-coding RNAs that, after maturation, are loaded onto the RISC effector complex that d...

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Detalles Bibliográficos
Autores principales: Cappella, Marisa, Perfetti, Alessandra, Cardinali, Beatrice, Garcia-Manteiga, Jose Manuel, Carrara, Matteo, Provenzano, Claudia, Fuschi, Paola, Cardani, Rosanna, Renna, Laura Valentina, Meola, Giovanni, Falcone, Germana, Martelli, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023919/
https://www.ncbi.nlm.nih.gov/pubmed/29955039
http://dx.doi.org/10.1038/s41419-018-0769-5

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