Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells

Highly active anti-retroviral therapy (HAART) cannot clear infected cells harboring HIV-1 proviral DNA from HIV-1-infected patients. We previously demonstrated that zinc-finger nucleases (ZFNs) can specifically and efficiently excise HIV-1 proviral DNA from latently infected human T cells by targeti...

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Detalles Bibliográficos
Autores principales: Ji, Haiyan, Lu, Panpan, Liu, Baochi, Qu, Xiying, Wang, Yanan, Jiang, Zhengtao, Yang, Xinyi, Zhong, Yangcheng, Yang, He, Pan, Hanyu, Zhao, Lin, Xu, Jianqing, Lu, Hongzhou, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023959/
https://www.ncbi.nlm.nih.gov/pubmed/30195798
http://dx.doi.org/10.1016/j.omtn.2018.04.014

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