Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review

Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide va...

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Detalles Bibliográficos
Autores principales: Xu, Wang-Dong, Huang, An-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023968/
https://www.ncbi.nlm.nih.gov/pubmed/29988385
http://dx.doi.org/10.3389/fimmu.2018.01462
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author Xu, Wang-Dong
Huang, An-Fang
author_facet Xu, Wang-Dong
Huang, An-Fang
author_sort Xu, Wang-Dong
collection PubMed
description Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide variety of diseases, including chronic inflammatory diseases. In this review, we discuss the expression and biological functions of IL-38, especially the role in rheumatic autoimmune diseases. Collection of the information may improve the understanding of IL-38, and may give potential for theoretical basis for clinical trials and drug development in the future.
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spelling pubmed-60239682018-07-09 Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review Xu, Wang-Dong Huang, An-Fang Front Immunol Immunology Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide variety of diseases, including chronic inflammatory diseases. In this review, we discuss the expression and biological functions of IL-38, especially the role in rheumatic autoimmune diseases. Collection of the information may improve the understanding of IL-38, and may give potential for theoretical basis for clinical trials and drug development in the future. Frontiers Media S.A. 2018-06-22 /pmc/articles/PMC6023968/ /pubmed/29988385 http://dx.doi.org/10.3389/fimmu.2018.01462 Text en Copyright © 2018 Xu and Huang. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xu, Wang-Dong
Huang, An-Fang
Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
title Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
title_full Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
title_fullStr Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
title_full_unstemmed Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
title_short Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
title_sort role of interleukin-38 in chronic inflammatory diseases: a comprehensive review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023968/
https://www.ncbi.nlm.nih.gov/pubmed/29988385
http://dx.doi.org/10.3389/fimmu.2018.01462
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