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NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

Natural killer (NK) cell-based immunotherapy is a promising therapy for cancer patients. Inhibitory killer immunoglobulin-like receptors (KIRs) and NKG2A are required for NK cell licensing, but can also inhibit NK cell effector function. Upon reconstitution in a stem cell transplantation setting or...

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Detalles Bibliográficos
Autores principales:	Mahaweni, Niken M., Ehlers, Femke A. I., Sarkar, Subhashis, Janssen, Johanna W. H., Tilanus, Marcel G. J., Bos, Gerard M. J., Wieten, Lotte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023990/ https://www.ncbi.nlm.nih.gov/pubmed/29988376 http://dx.doi.org/10.3389/fimmu.2018.01415

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