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IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis
Schizophrenia and treatment of this disorder are often accompanied with metabolic syndrome and cardiovascular issues. Alterations in the serum level of innate immune mediators, such as interleukin-33 (IL-33) and its receptor IL-33R (ST2) and Galectin-3 (Gal-3) were observed in these conditions. More...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024021/ https://www.ncbi.nlm.nih.gov/pubmed/29988422 http://dx.doi.org/10.3389/fpsyt.2018.00271 |
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author | Borovcanin, Milica M. Janicijevic, Slavica M. Jovanovic, Ivan P. Gajovic, Nevena Arsenijevic, Nebojsa N. Lukic, Miodrag L. |
author_facet | Borovcanin, Milica M. Janicijevic, Slavica M. Jovanovic, Ivan P. Gajovic, Nevena Arsenijevic, Nebojsa N. Lukic, Miodrag L. |
author_sort | Borovcanin, Milica M. |
collection | PubMed |
description | Schizophrenia and treatment of this disorder are often accompanied with metabolic syndrome and cardiovascular issues. Alterations in the serum level of innate immune mediators, such as interleukin-33 (IL-33) and its receptor IL-33R (ST2) and Galectin-3 (Gal-3) were observed in these conditions. Moreover, these parameters are potential prognostic and therapeutic markers. There is also accumulating evidence that these molecules play a role in neuroinflammation. Therefore, in this study we have investigated the serum level of Gal-3, IL-33 and soluble ST2 (sST2) in different stages of schizophrenia. Gal-3 levels were elevated in remission and lower in schizophrenia exacerbation in comparison with controls. Levels of IL-33 and sST2 are higher in schizophrenia exacerbation in comparison with controls and patients in remission. This initial analysis of new markers of neuroinflammation suggested their involvement in schizophrenia pathophysiology and/or cardiometabolic comorbidity. |
format | Online Article Text |
id | pubmed-6024021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60240212018-07-09 IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis Borovcanin, Milica M. Janicijevic, Slavica M. Jovanovic, Ivan P. Gajovic, Nevena Arsenijevic, Nebojsa N. Lukic, Miodrag L. Front Psychiatry Psychiatry Schizophrenia and treatment of this disorder are often accompanied with metabolic syndrome and cardiovascular issues. Alterations in the serum level of innate immune mediators, such as interleukin-33 (IL-33) and its receptor IL-33R (ST2) and Galectin-3 (Gal-3) were observed in these conditions. Moreover, these parameters are potential prognostic and therapeutic markers. There is also accumulating evidence that these molecules play a role in neuroinflammation. Therefore, in this study we have investigated the serum level of Gal-3, IL-33 and soluble ST2 (sST2) in different stages of schizophrenia. Gal-3 levels were elevated in remission and lower in schizophrenia exacerbation in comparison with controls. Levels of IL-33 and sST2 are higher in schizophrenia exacerbation in comparison with controls and patients in remission. This initial analysis of new markers of neuroinflammation suggested their involvement in schizophrenia pathophysiology and/or cardiometabolic comorbidity. Frontiers Media S.A. 2018-06-22 /pmc/articles/PMC6024021/ /pubmed/29988422 http://dx.doi.org/10.3389/fpsyt.2018.00271 Text en Copyright © 2018 Borovcanin, Janicijevic, Jovanovic, Gajovic, Arsenijevic and Lukic. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Borovcanin, Milica M. Janicijevic, Slavica M. Jovanovic, Ivan P. Gajovic, Nevena Arsenijevic, Nebojsa N. Lukic, Miodrag L. IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis |
title | IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis |
title_full | IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis |
title_fullStr | IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis |
title_full_unstemmed | IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis |
title_short | IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis |
title_sort | il-33/st2 pathway and galectin-3 as a new analytes in pathogenesis and cardiometabolic risk evaluation in psychosis |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024021/ https://www.ncbi.nlm.nih.gov/pubmed/29988422 http://dx.doi.org/10.3389/fpsyt.2018.00271 |
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