mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

Translation and decay of eukaryotic mRNAs is controlled by shortening of the poly(A) tail and release of the poly(A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two exonucleases—Ccr4 and Caf1/Pop2—that mediate mRNA deadenylation. Here, using a fully reconstituted biochemical system with...

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Detalles Bibliográficos
Autores principales: Webster, Michael W., Chen, Ying-Hsin, Stowell, James A.W., Alhusaini, Najwa, Sweet, Thomas, Graveley, Brenton R., Coller, Jeff, Passmore, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024076/
https://www.ncbi.nlm.nih.gov/pubmed/29932902
http://dx.doi.org/10.1016/j.molcel.2018.05.033

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