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Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review

The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer’s disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a...

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Detalles Bibliográficos
Autores principales: Liao, Huan, Zhu, Zhuoting, Peng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024140/
https://www.ncbi.nlm.nih.gov/pubmed/29988470
http://dx.doi.org/10.3389/fnagi.2018.00188
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author Liao, Huan
Zhu, Zhuoting
Peng, Ying
author_facet Liao, Huan
Zhu, Zhuoting
Peng, Ying
author_sort Liao, Huan
collection PubMed
description The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer’s disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and specific screening technology to identify high-risk individuals before cognitive symptoms arise. Even though current modalities, such as positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarker, showed their potential clinical uses in early detection of AD, the high cost, narrow isotope availability of PET probes and invasive characteristics of CSF biomarker limited their broad utility. Therefore, additional tools for detection of AD are needed. As a projection of the central nervous system (CNS), the retina has been described as a “window to the brain” and a novel marker for AD. Low cost, easy accessibility and non-invasive features make retina tests suitable for large-scale population screening and investigations of preclinical AD. Furthermore, a number of novel approaches in retina imaging, such as optical coherence tomography (OCT), have been developed and made it possible to visualize changes in the retina at a very fine resolution. In this review, we outline the background for AD to accelerate the adoption of retina imaging for the diagnosis and management of AD in clinical practice. Then, we focus on recent findings on the application of retina imaging to investigate AD and provide suggestions for future research directions.
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spelling pubmed-60241402018-07-09 Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review Liao, Huan Zhu, Zhuoting Peng, Ying Front Aging Neurosci Neuroscience The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer’s disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and specific screening technology to identify high-risk individuals before cognitive symptoms arise. Even though current modalities, such as positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarker, showed their potential clinical uses in early detection of AD, the high cost, narrow isotope availability of PET probes and invasive characteristics of CSF biomarker limited their broad utility. Therefore, additional tools for detection of AD are needed. As a projection of the central nervous system (CNS), the retina has been described as a “window to the brain” and a novel marker for AD. Low cost, easy accessibility and non-invasive features make retina tests suitable for large-scale population screening and investigations of preclinical AD. Furthermore, a number of novel approaches in retina imaging, such as optical coherence tomography (OCT), have been developed and made it possible to visualize changes in the retina at a very fine resolution. In this review, we outline the background for AD to accelerate the adoption of retina imaging for the diagnosis and management of AD in clinical practice. Then, we focus on recent findings on the application of retina imaging to investigate AD and provide suggestions for future research directions. Frontiers Media S.A. 2018-06-22 /pmc/articles/PMC6024140/ /pubmed/29988470 http://dx.doi.org/10.3389/fnagi.2018.00188 Text en Copyright © 2018 Liao, Zhu and Peng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liao, Huan
Zhu, Zhuoting
Peng, Ying
Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
title Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
title_full Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
title_fullStr Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
title_full_unstemmed Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
title_short Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
title_sort potential utility of retinal imaging for alzheimer’s disease: a review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024140/
https://www.ncbi.nlm.nih.gov/pubmed/29988470
http://dx.doi.org/10.3389/fnagi.2018.00188
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