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Rucaparib in ovarian cancer: an update on safety, efficacy and place in therapy

Rucaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor and potent inhibitor of PARP1, PARP2 and PARP3 enzymes. Phase II and III trials have documented that rucaparib has single-agent antitumor activity in patients with high-grade ovarian carcinoma, with both BRCA-mutated (germline and somatic)...

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Detalles Bibliográficos
Autores principales:	Dal Molin, Graziela Z., Omatsu, Kohei, Sood, Anil K., Coleman, Robert L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024342/ https://www.ncbi.nlm.nih.gov/pubmed/29977351 http://dx.doi.org/10.1177/1758835918778483

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