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Adiposity and Serum Selenium in U.S. Adults

Requirements for selenium and other antioxidant nutrients are increased in pro-oxidant and pro-inflammatory conditions such as excess adiposity. Data concerning the association of excess general and central adiposity with circulating selenium concentrations, however, are limited. We examined the cro...

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Autores principales: Zhong, Qiuan, Lin, Ruoxi, Nong, Qingjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024359/
https://www.ncbi.nlm.nih.gov/pubmed/29874857
http://dx.doi.org/10.3390/nu10060727
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author Zhong, Qiuan
Lin, Ruoxi
Nong, Qingjiao
author_facet Zhong, Qiuan
Lin, Ruoxi
Nong, Qingjiao
author_sort Zhong, Qiuan
collection PubMed
description Requirements for selenium and other antioxidant nutrients are increased in pro-oxidant and pro-inflammatory conditions such as excess adiposity. Data concerning the association of excess general and central adiposity with circulating selenium concentrations, however, are limited. We examined the cross-sectional associations of body mass index (BMI), percent body fat (%BF), and waist circumference (WC) with serum selenium concentrations in 6440 men and 6849 women aged ≥20 years who participated in the U.S. Third National Health and Nutrition Examination Survey. In multivariable analyses, the average difference (95% confidence interval (CI)) in serum selenium comparing the highest with the lowest quartiles of BMI was −4.0 (−5.5, −1.6) ng/mL in both men and women. These inverse associations were evident after further adjustment for WC. For %BF, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles of %BF were −1.7 (−4.2, 0.7) ng/mL in men and −4.5 (−7.0, −1.9) ng/mL in women. The inverse association in women persisted after adjusting for WC. For WC, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles were −1.9 (−3.8, −0.1) ng/mL in men and −3.9 (−5.8, −2.0) ng/mL in women. After further adjustment for BMI, the inverse association became positive in men and null in women. Our findings suggest that general and central adiposity have different associations with serum selenium levels and that these associations may depend on gender.
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spelling pubmed-60243592018-07-08 Adiposity and Serum Selenium in U.S. Adults Zhong, Qiuan Lin, Ruoxi Nong, Qingjiao Nutrients Article Requirements for selenium and other antioxidant nutrients are increased in pro-oxidant and pro-inflammatory conditions such as excess adiposity. Data concerning the association of excess general and central adiposity with circulating selenium concentrations, however, are limited. We examined the cross-sectional associations of body mass index (BMI), percent body fat (%BF), and waist circumference (WC) with serum selenium concentrations in 6440 men and 6849 women aged ≥20 years who participated in the U.S. Third National Health and Nutrition Examination Survey. In multivariable analyses, the average difference (95% confidence interval (CI)) in serum selenium comparing the highest with the lowest quartiles of BMI was −4.0 (−5.5, −1.6) ng/mL in both men and women. These inverse associations were evident after further adjustment for WC. For %BF, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles of %BF were −1.7 (−4.2, 0.7) ng/mL in men and −4.5 (−7.0, −1.9) ng/mL in women. The inverse association in women persisted after adjusting for WC. For WC, the average differences (95% CI) in serum selenium between the highest and the lowest quartiles were −1.9 (−3.8, −0.1) ng/mL in men and −3.9 (−5.8, −2.0) ng/mL in women. After further adjustment for BMI, the inverse association became positive in men and null in women. Our findings suggest that general and central adiposity have different associations with serum selenium levels and that these associations may depend on gender. MDPI 2018-06-05 /pmc/articles/PMC6024359/ /pubmed/29874857 http://dx.doi.org/10.3390/nu10060727 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhong, Qiuan
Lin, Ruoxi
Nong, Qingjiao
Adiposity and Serum Selenium in U.S. Adults
title Adiposity and Serum Selenium in U.S. Adults
title_full Adiposity and Serum Selenium in U.S. Adults
title_fullStr Adiposity and Serum Selenium in U.S. Adults
title_full_unstemmed Adiposity and Serum Selenium in U.S. Adults
title_short Adiposity and Serum Selenium in U.S. Adults
title_sort adiposity and serum selenium in u.s. adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024359/
https://www.ncbi.nlm.nih.gov/pubmed/29874857
http://dx.doi.org/10.3390/nu10060727
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