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Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Grapho Publications, LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024430/ https://www.ncbi.nlm.nih.gov/pubmed/30042983 http://dx.doi.org/10.18383/j.tom.2017.00021 |
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author | Biton, Inbal E. Stettner, Noa Brener, Ori Erez, Ayelet Harmelin, Alon Garbow, Joel R. |
author_facet | Biton, Inbal E. Stettner, Noa Brener, Ori Erez, Ayelet Harmelin, Alon Garbow, Joel R. |
author_sort | Biton, Inbal E. |
collection | PubMed |
description | Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate–induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations. |
format | Online Article Text |
id | pubmed-6024430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Grapho Publications, LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-60244302018-07-24 Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography Biton, Inbal E. Stettner, Noa Brener, Ori Erez, Ayelet Harmelin, Alon Garbow, Joel R. Tomography Research Articles Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate–induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations. Grapho Publications, LLC 2018-03 /pmc/articles/PMC6024430/ /pubmed/30042983 http://dx.doi.org/10.18383/j.tom.2017.00021 Text en © 2018 The Authors. Published by Grapho Publications, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Articles Biton, Inbal E. Stettner, Noa Brener, Ori Erez, Ayelet Harmelin, Alon Garbow, Joel R. Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography |
title | Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography |
title_full | Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography |
title_fullStr | Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography |
title_full_unstemmed | Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography |
title_short | Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography |
title_sort | assessing mucosal inflammation in a dss-induced colitis mouse model by mr colonography |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024430/ https://www.ncbi.nlm.nih.gov/pubmed/30042983 http://dx.doi.org/10.18383/j.tom.2017.00021 |
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