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Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography

Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mu...

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Autores principales: Biton, Inbal E., Stettner, Noa, Brener, Ori, Erez, Ayelet, Harmelin, Alon, Garbow, Joel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Grapho Publications, LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024430/
https://www.ncbi.nlm.nih.gov/pubmed/30042983
http://dx.doi.org/10.18383/j.tom.2017.00021
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author Biton, Inbal E.
Stettner, Noa
Brener, Ori
Erez, Ayelet
Harmelin, Alon
Garbow, Joel R.
author_facet Biton, Inbal E.
Stettner, Noa
Brener, Ori
Erez, Ayelet
Harmelin, Alon
Garbow, Joel R.
author_sort Biton, Inbal E.
collection PubMed
description Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate–induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations.
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spelling pubmed-60244302018-07-24 Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography Biton, Inbal E. Stettner, Noa Brener, Ori Erez, Ayelet Harmelin, Alon Garbow, Joel R. Tomography Research Articles Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate–induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations. Grapho Publications, LLC 2018-03 /pmc/articles/PMC6024430/ /pubmed/30042983 http://dx.doi.org/10.18383/j.tom.2017.00021 Text en © 2018 The Authors. Published by Grapho Publications, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Articles
Biton, Inbal E.
Stettner, Noa
Brener, Ori
Erez, Ayelet
Harmelin, Alon
Garbow, Joel R.
Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
title Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
title_full Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
title_fullStr Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
title_full_unstemmed Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
title_short Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
title_sort assessing mucosal inflammation in a dss-induced colitis mouse model by mr colonography
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024430/
https://www.ncbi.nlm.nih.gov/pubmed/30042983
http://dx.doi.org/10.18383/j.tom.2017.00021
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