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Signaling Pathways for Long-Term Memory Formation in the Cricket

Unraveling the molecular mechanisms underlying memory formation in insects and a comparison with those of mammals will contribute to a further understanding of the evolution of higher-brain functions. As it is for mammals, insect memory can be divided into at least two distinct phases: protein-indep...

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Autores principales: Matsumoto, Yukihisa, Matsumoto, Chihiro S., Mizunami, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024501/
https://www.ncbi.nlm.nih.gov/pubmed/29988479
http://dx.doi.org/10.3389/fpsyg.2018.01014
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author Matsumoto, Yukihisa
Matsumoto, Chihiro S.
Mizunami, Makoto
author_facet Matsumoto, Yukihisa
Matsumoto, Chihiro S.
Mizunami, Makoto
author_sort Matsumoto, Yukihisa
collection PubMed
description Unraveling the molecular mechanisms underlying memory formation in insects and a comparison with those of mammals will contribute to a further understanding of the evolution of higher-brain functions. As it is for mammals, insect memory can be divided into at least two distinct phases: protein-independent short-term memory and protein-dependent long-term memory (LTM). We have been investigating the signaling pathway of LTM formation by behavioral-pharmacological experiments using the cricket Gryllus bimaculatus, whose olfactory learning and memory abilities are among the highest in insect species. Our studies revealed that the NO-cGMP signaling pathway, CaMKII and PKA play crucial roles in LTM formation in crickets. These LTM formation signaling pathways in crickets share a number of attributes with those of mammals, and thus we conclude that insects, with relatively simple brain structures and neural circuitry, will also be beneficial in exploratory experiments to predict the molecular mechanisms underlying memory formation in mammals.
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spelling pubmed-60245012018-07-09 Signaling Pathways for Long-Term Memory Formation in the Cricket Matsumoto, Yukihisa Matsumoto, Chihiro S. Mizunami, Makoto Front Psychol Psychology Unraveling the molecular mechanisms underlying memory formation in insects and a comparison with those of mammals will contribute to a further understanding of the evolution of higher-brain functions. As it is for mammals, insect memory can be divided into at least two distinct phases: protein-independent short-term memory and protein-dependent long-term memory (LTM). We have been investigating the signaling pathway of LTM formation by behavioral-pharmacological experiments using the cricket Gryllus bimaculatus, whose olfactory learning and memory abilities are among the highest in insect species. Our studies revealed that the NO-cGMP signaling pathway, CaMKII and PKA play crucial roles in LTM formation in crickets. These LTM formation signaling pathways in crickets share a number of attributes with those of mammals, and thus we conclude that insects, with relatively simple brain structures and neural circuitry, will also be beneficial in exploratory experiments to predict the molecular mechanisms underlying memory formation in mammals. Frontiers Media S.A. 2018-06-22 /pmc/articles/PMC6024501/ /pubmed/29988479 http://dx.doi.org/10.3389/fpsyg.2018.01014 Text en Copyright © 2018 Matsumoto, Matsumoto and Mizunami. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Matsumoto, Yukihisa
Matsumoto, Chihiro S.
Mizunami, Makoto
Signaling Pathways for Long-Term Memory Formation in the Cricket
title Signaling Pathways for Long-Term Memory Formation in the Cricket
title_full Signaling Pathways for Long-Term Memory Formation in the Cricket
title_fullStr Signaling Pathways for Long-Term Memory Formation in the Cricket
title_full_unstemmed Signaling Pathways for Long-Term Memory Formation in the Cricket
title_short Signaling Pathways for Long-Term Memory Formation in the Cricket
title_sort signaling pathways for long-term memory formation in the cricket
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024501/
https://www.ncbi.nlm.nih.gov/pubmed/29988479
http://dx.doi.org/10.3389/fpsyg.2018.01014
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