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Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner

Voltage-gated sodium channel Nav1.7 is a key molecule in nociception, and its dysfunction has been associated with various pain disorders. Here, we investigated the regulation of Nav1.7 biophysical properties by Fyn, an Src family tyrosine kinase. Nav1.7 was coexpressed with either constitutively ac...

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Detalles Bibliográficos
Autores principales:	Li, Yangyang, Zhu, Tengteng, Yang, Huan, Dib-Hajj, Sulayman D, Waxman, Stephen G, Yu, Ye, Xu, Tian-Le, Cheng, Xiaoyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024516/ https://www.ncbi.nlm.nih.gov/pubmed/29790812 http://dx.doi.org/10.1177/1744806918782229

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