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Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Few studies have evaluated the association between diet and mental disorders, and it has been established that ω-3 (n-3) fatty acids may have a beneficial effect for sufferers of anxiety disorders. This study is part of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)—a population-base...

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Autores principales: Natacci, Lara, M. Marchioni, Dirce, C. Goulart, Alessandra, Nunes, Maria Angélica, B. Moreno, Arlinda, O. Cardoso, Letícia, Giatti, Luana, B. Molina, Maria del Carmen, S. Santos, Itamar, R. Brunoni, André, A. Lotufo, Paulo, M. Bensenor, Isabela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024589/
https://www.ncbi.nlm.nih.gov/pubmed/29882923
http://dx.doi.org/10.3390/nu10060663
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author Natacci, Lara
M. Marchioni, Dirce
C. Goulart, Alessandra
Nunes, Maria Angélica
B. Moreno, Arlinda
O. Cardoso, Letícia
Giatti, Luana
B. Molina, Maria del Carmen
S. Santos, Itamar
R. Brunoni, André
A. Lotufo, Paulo
M. Bensenor, Isabela
author_facet Natacci, Lara
M. Marchioni, Dirce
C. Goulart, Alessandra
Nunes, Maria Angélica
B. Moreno, Arlinda
O. Cardoso, Letícia
Giatti, Luana
B. Molina, Maria del Carmen
S. Santos, Itamar
R. Brunoni, André
A. Lotufo, Paulo
M. Bensenor, Isabela
author_sort Natacci, Lara
collection PubMed
description Few studies have evaluated the association between diet and mental disorders, and it has been established that ω-3 (n-3) fatty acids may have a beneficial effect for sufferers of anxiety disorders. This study is part of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)—a population-based cohort study on diet and mental health—and searched for associations between anxiety disorders and consumption of n-3 polyunsaturated fatty acids (PUFA). The study had a cross-sectional design, with a total sample of 12,268 adults. Dietary exposure was measured by a quantitative food-frequency questionnaire, and mental diagnoses were assessed by the Clinical Interview Schedule—Revised Version and diagnosed according to the International Classification of Diseases (ICD-10). Logistic regression models were built using quintiles of n-3, ω 6 (n-6), n-6/n-3 ratio, and PUFA, using the 1st quintile as reference. Anxiety disorders were identified in 15.4% of the sample. After adjusting for sociodemographic variables, cardiovascular risk factors, diet variables, and depression, intakes in the 5th quintile were inversely associated with anxiety disorders for EPA (OR = 0.82, 95% CI = 0.69–0.98), DHA (OR = 0.83, 95% CI = 0.69–0.98), and DPA (OR = 0.82, 95% CI = 0.69–0.98). Participants in the fifth quintile of n-6/n-3 ratio had a positive association with anxiety disorders. Although results suggest a possible protective effect of n-3 fatty acids against anxiety, all associations lost significance after adjustment for multiple comparisons.
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spelling pubmed-60245892018-07-08 Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Natacci, Lara M. Marchioni, Dirce C. Goulart, Alessandra Nunes, Maria Angélica B. Moreno, Arlinda O. Cardoso, Letícia Giatti, Luana B. Molina, Maria del Carmen S. Santos, Itamar R. Brunoni, André A. Lotufo, Paulo M. Bensenor, Isabela Nutrients Article Few studies have evaluated the association between diet and mental disorders, and it has been established that ω-3 (n-3) fatty acids may have a beneficial effect for sufferers of anxiety disorders. This study is part of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)—a population-based cohort study on diet and mental health—and searched for associations between anxiety disorders and consumption of n-3 polyunsaturated fatty acids (PUFA). The study had a cross-sectional design, with a total sample of 12,268 adults. Dietary exposure was measured by a quantitative food-frequency questionnaire, and mental diagnoses were assessed by the Clinical Interview Schedule—Revised Version and diagnosed according to the International Classification of Diseases (ICD-10). Logistic regression models were built using quintiles of n-3, ω 6 (n-6), n-6/n-3 ratio, and PUFA, using the 1st quintile as reference. Anxiety disorders were identified in 15.4% of the sample. After adjusting for sociodemographic variables, cardiovascular risk factors, diet variables, and depression, intakes in the 5th quintile were inversely associated with anxiety disorders for EPA (OR = 0.82, 95% CI = 0.69–0.98), DHA (OR = 0.83, 95% CI = 0.69–0.98), and DPA (OR = 0.82, 95% CI = 0.69–0.98). Participants in the fifth quintile of n-6/n-3 ratio had a positive association with anxiety disorders. Although results suggest a possible protective effect of n-3 fatty acids against anxiety, all associations lost significance after adjustment for multiple comparisons. MDPI 2018-05-24 /pmc/articles/PMC6024589/ /pubmed/29882923 http://dx.doi.org/10.3390/nu10060663 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Natacci, Lara
M. Marchioni, Dirce
C. Goulart, Alessandra
Nunes, Maria Angélica
B. Moreno, Arlinda
O. Cardoso, Letícia
Giatti, Luana
B. Molina, Maria del Carmen
S. Santos, Itamar
R. Brunoni, André
A. Lotufo, Paulo
M. Bensenor, Isabela
Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_full Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_fullStr Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_full_unstemmed Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_short Omega 3 Consumption and Anxiety Disorders: A Cross-Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_sort omega 3 consumption and anxiety disorders: a cross-sectional analysis of the brazilian longitudinal study of adult health (elsa-brasil)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024589/
https://www.ncbi.nlm.nih.gov/pubmed/29882923
http://dx.doi.org/10.3390/nu10060663
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