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Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis

Liver cirrhosis is often associated with increased inflammatory responses and changes of glutathione (GSH) status. The possible interactions between these two factors in mediating damages of liver function remain unclear. Here, we measured the inflammatory responses and GSH status in liver cirrhotic...

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Autores principales: Lai, Chia-Yu, Cheng, Shao-Bin, Lee, Teng-Yu, Liu, Hsiao-Tien, Huang, Shih-Chien, Huang, Yi-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024608/
https://www.ncbi.nlm.nih.gov/pubmed/29861471
http://dx.doi.org/10.3390/nu10060678
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author Lai, Chia-Yu
Cheng, Shao-Bin
Lee, Teng-Yu
Liu, Hsiao-Tien
Huang, Shih-Chien
Huang, Yi-Chia
author_facet Lai, Chia-Yu
Cheng, Shao-Bin
Lee, Teng-Yu
Liu, Hsiao-Tien
Huang, Shih-Chien
Huang, Yi-Chia
author_sort Lai, Chia-Yu
collection PubMed
description Liver cirrhosis is often associated with increased inflammatory responses and changes of glutathione (GSH) status. The possible interactions between these two factors in mediating damages of liver function remain unclear. Here, we measured the inflammatory responses and GSH status in liver cirrhotic patients and compared them with healthy subjects. In addition, we assessed the relationship of the GSH status and levels of inflammatory markers with the severity of the disease. This was a cross-sectional study. In total, we recruited 63 liver cirrhotic patients with Child–Turcotte–Pugh class A scores, and 12 patients with class B–C scores, together with 110 healthy subjects. Patients with class B–C scores showed the highest level of high-sensitivity C-reactive protein (hs-CRP) when compared with class A patients or healthy subjects. Patients in class A group had significantly higher GSH levels when compared with class B–C group or healthy subjects. After adjusting for potential confounders and each other, serum hs-CRP levels showed positive association with the Child–Turcotte–Pugh scores, while GSH levels showed negative association with Child–Turcotte–Pugh scores. Interactions were found between levels of plasma GSH and serum hs-CRP (β = 0.004, p = 0.016). CRP and GSH levels, which had showed interactions, were associated with the severity of liver cirrhosis.
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spelling pubmed-60246082018-07-08 Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis Lai, Chia-Yu Cheng, Shao-Bin Lee, Teng-Yu Liu, Hsiao-Tien Huang, Shih-Chien Huang, Yi-Chia Nutrients Article Liver cirrhosis is often associated with increased inflammatory responses and changes of glutathione (GSH) status. The possible interactions between these two factors in mediating damages of liver function remain unclear. Here, we measured the inflammatory responses and GSH status in liver cirrhotic patients and compared them with healthy subjects. In addition, we assessed the relationship of the GSH status and levels of inflammatory markers with the severity of the disease. This was a cross-sectional study. In total, we recruited 63 liver cirrhotic patients with Child–Turcotte–Pugh class A scores, and 12 patients with class B–C scores, together with 110 healthy subjects. Patients with class B–C scores showed the highest level of high-sensitivity C-reactive protein (hs-CRP) when compared with class A patients or healthy subjects. Patients in class A group had significantly higher GSH levels when compared with class B–C group or healthy subjects. After adjusting for potential confounders and each other, serum hs-CRP levels showed positive association with the Child–Turcotte–Pugh scores, while GSH levels showed negative association with Child–Turcotte–Pugh scores. Interactions were found between levels of plasma GSH and serum hs-CRP (β = 0.004, p = 0.016). CRP and GSH levels, which had showed interactions, were associated with the severity of liver cirrhosis. MDPI 2018-05-27 /pmc/articles/PMC6024608/ /pubmed/29861471 http://dx.doi.org/10.3390/nu10060678 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lai, Chia-Yu
Cheng, Shao-Bin
Lee, Teng-Yu
Liu, Hsiao-Tien
Huang, Shih-Chien
Huang, Yi-Chia
Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis
title Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis
title_full Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis
title_fullStr Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis
title_full_unstemmed Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis
title_short Possible Synergistic Effects of Glutathione and C-Reactive Protein in the Progression of Liver Cirrhosis
title_sort possible synergistic effects of glutathione and c-reactive protein in the progression of liver cirrhosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024608/
https://www.ncbi.nlm.nih.gov/pubmed/29861471
http://dx.doi.org/10.3390/nu10060678
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