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A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial

Recent literature suggests that catalytic doses (≤10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people with and without type 2 diabetes by inducing glycogen synthesis. To assess the effect of small single doses of fructos...

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Autores principales: Braunstein, Catherine R., Noronha, Jarvis C., Glenn, Andrea J., Viguiliouk, Effie, Noseworthy, Rebecca, Khan, Tauseef A., Au-Yeung, Fei, Blanco Mejia, Sonia, Wolever, Thomas M.S., Josse, Robert G., Kendall, Cyril W.C., Sievenpiper, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024645/
https://www.ncbi.nlm.nih.gov/pubmed/29890724
http://dx.doi.org/10.3390/nu10060750
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author Braunstein, Catherine R.
Noronha, Jarvis C.
Glenn, Andrea J.
Viguiliouk, Effie
Noseworthy, Rebecca
Khan, Tauseef A.
Au-Yeung, Fei
Blanco Mejia, Sonia
Wolever, Thomas M.S.
Josse, Robert G.
Kendall, Cyril W.C.
Sievenpiper, John L.
author_facet Braunstein, Catherine R.
Noronha, Jarvis C.
Glenn, Andrea J.
Viguiliouk, Effie
Noseworthy, Rebecca
Khan, Tauseef A.
Au-Yeung, Fei
Blanco Mejia, Sonia
Wolever, Thomas M.S.
Josse, Robert G.
Kendall, Cyril W.C.
Sievenpiper, John L.
author_sort Braunstein, Catherine R.
collection PubMed
description Recent literature suggests that catalytic doses (≤10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people with and without type 2 diabetes by inducing glycogen synthesis. To assess the effect of small single doses of fructose and allulose on postprandial blood glucose regulation in response to a 75 g-oral glucose tolerance test (75 g-OGTT) in healthy individuals, we conducted an acute randomized, crossover, equivalence trial in healthy adults. Each participant randomly received six treatments, separated by a minimum one-week washout. Treatments consisted of a 75 g-OGTT with the addition of fructose or allulose at 0 g (control), 5 g or 10 g. A standard 75 g-OGTT protocol was followed with blood samples at −30, 0, 30, 60, 90, 120 min. The primary outcome was the difference in plasma glucose incremental area under the curve (iAUC). A total of 27 participants underwent randomization with data available from 25 participants. Small doses of fructose or allulose did not show a significant effect on plasma glucose iAUC or other secondary markers of postprandial blood glucose regulation in response to a 75 g-OGTT in healthy individuals. These results were limited by the low power to detect a significant difference, owing to greater than expected intra-individual coefficient of variation (CV) in plasma glucose iAUC. Overall, we failed to confirm the catalytic effects of small doses of fructose and allulose in healthy individuals. Future trials may consider recruiting larger sample sizes of healthy individuals. Trial registration: clinicaltrials.gov identifier, NCT02459834.
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spelling pubmed-60246452018-07-08 A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial Braunstein, Catherine R. Noronha, Jarvis C. Glenn, Andrea J. Viguiliouk, Effie Noseworthy, Rebecca Khan, Tauseef A. Au-Yeung, Fei Blanco Mejia, Sonia Wolever, Thomas M.S. Josse, Robert G. Kendall, Cyril W.C. Sievenpiper, John L. Nutrients Article Recent literature suggests that catalytic doses (≤10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people with and without type 2 diabetes by inducing glycogen synthesis. To assess the effect of small single doses of fructose and allulose on postprandial blood glucose regulation in response to a 75 g-oral glucose tolerance test (75 g-OGTT) in healthy individuals, we conducted an acute randomized, crossover, equivalence trial in healthy adults. Each participant randomly received six treatments, separated by a minimum one-week washout. Treatments consisted of a 75 g-OGTT with the addition of fructose or allulose at 0 g (control), 5 g or 10 g. A standard 75 g-OGTT protocol was followed with blood samples at −30, 0, 30, 60, 90, 120 min. The primary outcome was the difference in plasma glucose incremental area under the curve (iAUC). A total of 27 participants underwent randomization with data available from 25 participants. Small doses of fructose or allulose did not show a significant effect on plasma glucose iAUC or other secondary markers of postprandial blood glucose regulation in response to a 75 g-OGTT in healthy individuals. These results were limited by the low power to detect a significant difference, owing to greater than expected intra-individual coefficient of variation (CV) in plasma glucose iAUC. Overall, we failed to confirm the catalytic effects of small doses of fructose and allulose in healthy individuals. Future trials may consider recruiting larger sample sizes of healthy individuals. Trial registration: clinicaltrials.gov identifier, NCT02459834. MDPI 2018-06-09 /pmc/articles/PMC6024645/ /pubmed/29890724 http://dx.doi.org/10.3390/nu10060750 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Braunstein, Catherine R.
Noronha, Jarvis C.
Glenn, Andrea J.
Viguiliouk, Effie
Noseworthy, Rebecca
Khan, Tauseef A.
Au-Yeung, Fei
Blanco Mejia, Sonia
Wolever, Thomas M.S.
Josse, Robert G.
Kendall, Cyril W.C.
Sievenpiper, John L.
A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
title A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
title_full A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
title_fullStr A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
title_full_unstemmed A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
title_short A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
title_sort double-blind, randomized controlled, acute feeding equivalence trial of small, catalytic doses of fructose and allulose on postprandial blood glucose metabolism in healthy participants: the fructose and allulose catalytic effects (face) trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024645/
https://www.ncbi.nlm.nih.gov/pubmed/29890724
http://dx.doi.org/10.3390/nu10060750
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