Cargando…
A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial
Recent literature suggests that catalytic doses (≤10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people with and without type 2 diabetes by inducing glycogen synthesis. To assess the effect of small single doses of fructos...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024645/ https://www.ncbi.nlm.nih.gov/pubmed/29890724 http://dx.doi.org/10.3390/nu10060750 |
_version_ | 1783336100029267968 |
---|---|
author | Braunstein, Catherine R. Noronha, Jarvis C. Glenn, Andrea J. Viguiliouk, Effie Noseworthy, Rebecca Khan, Tauseef A. Au-Yeung, Fei Blanco Mejia, Sonia Wolever, Thomas M.S. Josse, Robert G. Kendall, Cyril W.C. Sievenpiper, John L. |
author_facet | Braunstein, Catherine R. Noronha, Jarvis C. Glenn, Andrea J. Viguiliouk, Effie Noseworthy, Rebecca Khan, Tauseef A. Au-Yeung, Fei Blanco Mejia, Sonia Wolever, Thomas M.S. Josse, Robert G. Kendall, Cyril W.C. Sievenpiper, John L. |
author_sort | Braunstein, Catherine R. |
collection | PubMed |
description | Recent literature suggests that catalytic doses (≤10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people with and without type 2 diabetes by inducing glycogen synthesis. To assess the effect of small single doses of fructose and allulose on postprandial blood glucose regulation in response to a 75 g-oral glucose tolerance test (75 g-OGTT) in healthy individuals, we conducted an acute randomized, crossover, equivalence trial in healthy adults. Each participant randomly received six treatments, separated by a minimum one-week washout. Treatments consisted of a 75 g-OGTT with the addition of fructose or allulose at 0 g (control), 5 g or 10 g. A standard 75 g-OGTT protocol was followed with blood samples at −30, 0, 30, 60, 90, 120 min. The primary outcome was the difference in plasma glucose incremental area under the curve (iAUC). A total of 27 participants underwent randomization with data available from 25 participants. Small doses of fructose or allulose did not show a significant effect on plasma glucose iAUC or other secondary markers of postprandial blood glucose regulation in response to a 75 g-OGTT in healthy individuals. These results were limited by the low power to detect a significant difference, owing to greater than expected intra-individual coefficient of variation (CV) in plasma glucose iAUC. Overall, we failed to confirm the catalytic effects of small doses of fructose and allulose in healthy individuals. Future trials may consider recruiting larger sample sizes of healthy individuals. Trial registration: clinicaltrials.gov identifier, NCT02459834. |
format | Online Article Text |
id | pubmed-6024645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60246452018-07-08 A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial Braunstein, Catherine R. Noronha, Jarvis C. Glenn, Andrea J. Viguiliouk, Effie Noseworthy, Rebecca Khan, Tauseef A. Au-Yeung, Fei Blanco Mejia, Sonia Wolever, Thomas M.S. Josse, Robert G. Kendall, Cyril W.C. Sievenpiper, John L. Nutrients Article Recent literature suggests that catalytic doses (≤10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people with and without type 2 diabetes by inducing glycogen synthesis. To assess the effect of small single doses of fructose and allulose on postprandial blood glucose regulation in response to a 75 g-oral glucose tolerance test (75 g-OGTT) in healthy individuals, we conducted an acute randomized, crossover, equivalence trial in healthy adults. Each participant randomly received six treatments, separated by a minimum one-week washout. Treatments consisted of a 75 g-OGTT with the addition of fructose or allulose at 0 g (control), 5 g or 10 g. A standard 75 g-OGTT protocol was followed with blood samples at −30, 0, 30, 60, 90, 120 min. The primary outcome was the difference in plasma glucose incremental area under the curve (iAUC). A total of 27 participants underwent randomization with data available from 25 participants. Small doses of fructose or allulose did not show a significant effect on plasma glucose iAUC or other secondary markers of postprandial blood glucose regulation in response to a 75 g-OGTT in healthy individuals. These results were limited by the low power to detect a significant difference, owing to greater than expected intra-individual coefficient of variation (CV) in plasma glucose iAUC. Overall, we failed to confirm the catalytic effects of small doses of fructose and allulose in healthy individuals. Future trials may consider recruiting larger sample sizes of healthy individuals. Trial registration: clinicaltrials.gov identifier, NCT02459834. MDPI 2018-06-09 /pmc/articles/PMC6024645/ /pubmed/29890724 http://dx.doi.org/10.3390/nu10060750 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Braunstein, Catherine R. Noronha, Jarvis C. Glenn, Andrea J. Viguiliouk, Effie Noseworthy, Rebecca Khan, Tauseef A. Au-Yeung, Fei Blanco Mejia, Sonia Wolever, Thomas M.S. Josse, Robert G. Kendall, Cyril W.C. Sievenpiper, John L. A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial |
title | A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial |
title_full | A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial |
title_fullStr | A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial |
title_full_unstemmed | A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial |
title_short | A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial |
title_sort | double-blind, randomized controlled, acute feeding equivalence trial of small, catalytic doses of fructose and allulose on postprandial blood glucose metabolism in healthy participants: the fructose and allulose catalytic effects (face) trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024645/ https://www.ncbi.nlm.nih.gov/pubmed/29890724 http://dx.doi.org/10.3390/nu10060750 |
work_keys_str_mv | AT braunsteincatheriner adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT noronhajarvisc adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT glennandreaj adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT viguilioukeffie adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT noseworthyrebecca adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT khantauseefa adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT auyeungfei adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT blancomejiasonia adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT woleverthomasms adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT josserobertg adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT kendallcyrilwc adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT sievenpiperjohnl adoubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT braunsteincatheriner doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT noronhajarvisc doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT glennandreaj doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT viguilioukeffie doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT noseworthyrebecca doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT khantauseefa doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT auyeungfei doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT blancomejiasonia doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT woleverthomasms doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT josserobertg doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT kendallcyrilwc doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial AT sievenpiperjohnl doubleblindrandomizedcontrolledacutefeedingequivalencetrialofsmallcatalyticdosesoffructoseandalluloseonpostprandialbloodglucosemetabolisminhealthyparticipantsthefructoseandallulosecatalyticeffectsfacetrial |