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Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up
Vitamin K participates in brain physiology. This study aimed to determine whether using vitamin K antagonists (VKAs), which interfere with the vitamin K cycle, were (i) cross-sectionally associated with altered cognitive performance, and (ii) independent predictors of cognitive changes in older adul...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024671/ https://www.ncbi.nlm.nih.gov/pubmed/29794977 http://dx.doi.org/10.3390/nu10060666 |
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author | Brangier, Antoine Ferland, Guylaine Rolland, Yves Gautier, Jennifer Féart, Catherine Annweiler, Cedric |
author_facet | Brangier, Antoine Ferland, Guylaine Rolland, Yves Gautier, Jennifer Féart, Catherine Annweiler, Cedric |
author_sort | Brangier, Antoine |
collection | PubMed |
description | Vitamin K participates in brain physiology. This study aimed to determine whether using vitamin K antagonists (VKAs), which interfere with the vitamin K cycle, were (i) cross-sectionally associated with altered cognitive performance, and (ii) independent predictors of cognitive changes in older adults over 24 months. Information was collected on the use of VKAs (i.e., warfarin, acenocoumarol, and fluindione) among 378 geriatric outpatients (mean, 82.3 ± 5.6 years; 60.1% female). Global cognitive performance and executive functions were assessed with Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) scores, respectively, at baseline and after 12 and 24 months of follow-up. Age, gender, body mass index, mean arterial pressure, disability, gait speed, comorbidities, atrial fibrillation, stroke, carotid artery stenosis, leukoaraiosis grade on computed tomography (CT) scan, psychoactive drugs, antidementia drugs, blood-thinning drugs (i.e., anticoagulants other than VKAs, antiplatelet medications), serum creatinine levels, and vitamin B12 concentrations were considered as potential confounders. Using VKAs was associated with lower (i.e., worse) FAB score at baseline (adjusted β = −2.1, p = 0.026), and with a decrease in FAB score after 24 months (adjusted β = −203.6%, p = 0.010), but not after 12 months (p = 0.659). Using VKAs was not associated with any change in MMSE score at baseline (p = 0.655), after 12 months (p = 0.603), or after 24 months (p = 0.201). In conclusion, we found more severe executive dysfunction at baseline and incident executive decline over 24 months among geriatric patients using VKAs, when compared with their counterparts. |
format | Online Article Text |
id | pubmed-6024671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60246712018-07-08 Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up Brangier, Antoine Ferland, Guylaine Rolland, Yves Gautier, Jennifer Féart, Catherine Annweiler, Cedric Nutrients Article Vitamin K participates in brain physiology. This study aimed to determine whether using vitamin K antagonists (VKAs), which interfere with the vitamin K cycle, were (i) cross-sectionally associated with altered cognitive performance, and (ii) independent predictors of cognitive changes in older adults over 24 months. Information was collected on the use of VKAs (i.e., warfarin, acenocoumarol, and fluindione) among 378 geriatric outpatients (mean, 82.3 ± 5.6 years; 60.1% female). Global cognitive performance and executive functions were assessed with Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) scores, respectively, at baseline and after 12 and 24 months of follow-up. Age, gender, body mass index, mean arterial pressure, disability, gait speed, comorbidities, atrial fibrillation, stroke, carotid artery stenosis, leukoaraiosis grade on computed tomography (CT) scan, psychoactive drugs, antidementia drugs, blood-thinning drugs (i.e., anticoagulants other than VKAs, antiplatelet medications), serum creatinine levels, and vitamin B12 concentrations were considered as potential confounders. Using VKAs was associated with lower (i.e., worse) FAB score at baseline (adjusted β = −2.1, p = 0.026), and with a decrease in FAB score after 24 months (adjusted β = −203.6%, p = 0.010), but not after 12 months (p = 0.659). Using VKAs was not associated with any change in MMSE score at baseline (p = 0.655), after 12 months (p = 0.603), or after 24 months (p = 0.201). In conclusion, we found more severe executive dysfunction at baseline and incident executive decline over 24 months among geriatric patients using VKAs, when compared with their counterparts. MDPI 2018-05-24 /pmc/articles/PMC6024671/ /pubmed/29794977 http://dx.doi.org/10.3390/nu10060666 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Brangier, Antoine Ferland, Guylaine Rolland, Yves Gautier, Jennifer Féart, Catherine Annweiler, Cedric Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up |
title | Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up |
title_full | Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up |
title_fullStr | Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up |
title_full_unstemmed | Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up |
title_short | Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up |
title_sort | vitamin k antagonists and cognitive decline in older adults: a 24-month follow-up |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024671/ https://www.ncbi.nlm.nih.gov/pubmed/29794977 http://dx.doi.org/10.3390/nu10060666 |
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