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Consolidation and Exacerbation of COPD
Twenty percent of chronic obstructive pulmonary disease (COPD) patients admitted to hospital because of an ‘exacerbation’ will have consolidation visible on a chest X-ray. The presence of consolidation is associated with higher mortality. Imperfect definitions of COPD exacerbation and pneumonia, and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024675/ https://www.ncbi.nlm.nih.gov/pubmed/29865214 http://dx.doi.org/10.3390/medsci6020044 |
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author | Hurst, John R. |
author_facet | Hurst, John R. |
author_sort | Hurst, John R. |
collection | PubMed |
description | Twenty percent of chronic obstructive pulmonary disease (COPD) patients admitted to hospital because of an ‘exacerbation’ will have consolidation visible on a chest X-ray. The presence of consolidation is associated with higher mortality. Imperfect definitions of COPD exacerbation and pneumonia, and incomplete and imperfect diagnostic tests, have resulted in a debate about whether these episodes are best thought of as ‘exacerbation with consolidation’ or ‘pneumonia in a person with COPD’. With the current views that exacerbations are not all identical, and that they can be ‘phenotyped’ to identify episodes with different prognosis and treatment response, perhaps these episodes are best-considered a phenotype of exacerbation. Whatever the terminology, the important clinical message is to recognise that those with consolidation have higher mortality, and likely different responses to treatment. |
format | Online Article Text |
id | pubmed-6024675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60246752018-07-05 Consolidation and Exacerbation of COPD Hurst, John R. Med Sci (Basel) Review Twenty percent of chronic obstructive pulmonary disease (COPD) patients admitted to hospital because of an ‘exacerbation’ will have consolidation visible on a chest X-ray. The presence of consolidation is associated with higher mortality. Imperfect definitions of COPD exacerbation and pneumonia, and incomplete and imperfect diagnostic tests, have resulted in a debate about whether these episodes are best thought of as ‘exacerbation with consolidation’ or ‘pneumonia in a person with COPD’. With the current views that exacerbations are not all identical, and that they can be ‘phenotyped’ to identify episodes with different prognosis and treatment response, perhaps these episodes are best-considered a phenotype of exacerbation. Whatever the terminology, the important clinical message is to recognise that those with consolidation have higher mortality, and likely different responses to treatment. MDPI 2018-06-01 /pmc/articles/PMC6024675/ /pubmed/29865214 http://dx.doi.org/10.3390/medsci6020044 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hurst, John R. Consolidation and Exacerbation of COPD |
title | Consolidation and Exacerbation of COPD |
title_full | Consolidation and Exacerbation of COPD |
title_fullStr | Consolidation and Exacerbation of COPD |
title_full_unstemmed | Consolidation and Exacerbation of COPD |
title_short | Consolidation and Exacerbation of COPD |
title_sort | consolidation and exacerbation of copd |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024675/ https://www.ncbi.nlm.nih.gov/pubmed/29865214 http://dx.doi.org/10.3390/medsci6020044 |
work_keys_str_mv | AT hurstjohnr consolidationandexacerbationofcopd |