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Consolidation and Exacerbation of COPD

Twenty percent of chronic obstructive pulmonary disease (COPD) patients admitted to hospital because of an ‘exacerbation’ will have consolidation visible on a chest X-ray. The presence of consolidation is associated with higher mortality. Imperfect definitions of COPD exacerbation and pneumonia, and...

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Detalles Bibliográficos
Autor principal: Hurst, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024675/
https://www.ncbi.nlm.nih.gov/pubmed/29865214
http://dx.doi.org/10.3390/medsci6020044
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author Hurst, John R.
author_facet Hurst, John R.
author_sort Hurst, John R.
collection PubMed
description Twenty percent of chronic obstructive pulmonary disease (COPD) patients admitted to hospital because of an ‘exacerbation’ will have consolidation visible on a chest X-ray. The presence of consolidation is associated with higher mortality. Imperfect definitions of COPD exacerbation and pneumonia, and incomplete and imperfect diagnostic tests, have resulted in a debate about whether these episodes are best thought of as ‘exacerbation with consolidation’ or ‘pneumonia in a person with COPD’. With the current views that exacerbations are not all identical, and that they can be ‘phenotyped’ to identify episodes with different prognosis and treatment response, perhaps these episodes are best-considered a phenotype of exacerbation. Whatever the terminology, the important clinical message is to recognise that those with consolidation have higher mortality, and likely different responses to treatment.
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spelling pubmed-60246752018-07-05 Consolidation and Exacerbation of COPD Hurst, John R. Med Sci (Basel) Review Twenty percent of chronic obstructive pulmonary disease (COPD) patients admitted to hospital because of an ‘exacerbation’ will have consolidation visible on a chest X-ray. The presence of consolidation is associated with higher mortality. Imperfect definitions of COPD exacerbation and pneumonia, and incomplete and imperfect diagnostic tests, have resulted in a debate about whether these episodes are best thought of as ‘exacerbation with consolidation’ or ‘pneumonia in a person with COPD’. With the current views that exacerbations are not all identical, and that they can be ‘phenotyped’ to identify episodes with different prognosis and treatment response, perhaps these episodes are best-considered a phenotype of exacerbation. Whatever the terminology, the important clinical message is to recognise that those with consolidation have higher mortality, and likely different responses to treatment. MDPI 2018-06-01 /pmc/articles/PMC6024675/ /pubmed/29865214 http://dx.doi.org/10.3390/medsci6020044 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hurst, John R.
Consolidation and Exacerbation of COPD
title Consolidation and Exacerbation of COPD
title_full Consolidation and Exacerbation of COPD
title_fullStr Consolidation and Exacerbation of COPD
title_full_unstemmed Consolidation and Exacerbation of COPD
title_short Consolidation and Exacerbation of COPD
title_sort consolidation and exacerbation of copd
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024675/
https://www.ncbi.nlm.nih.gov/pubmed/29865214
http://dx.doi.org/10.3390/medsci6020044
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