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Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food

Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of partic...

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Autores principales: Fernández, Javier, Guerra, Beatriz, Rodicio, M. Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024723/
https://www.ncbi.nlm.nih.gov/pubmed/29642473
http://dx.doi.org/10.3390/vetsci5020040
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author Fernández, Javier
Guerra, Beatriz
Rodicio, M. Rosario
author_facet Fernández, Javier
Guerra, Beatriz
Rodicio, M. Rosario
author_sort Fernández, Javier
collection PubMed
description Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical “last resort” antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli, and Enterobacter, which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS. Nevertheless, it has already been detected in isolates recovered from humans, companion animals, livestock, wild animals, and food. Five carbapenemases with major clinical importance—namely KPC (Klebsiella pneumoniae carbapenemase) (class A), IMP (imipenemase), NDM (New Delhi metallo-β-lactamase), VIM (Verona integron-encoded metallo-β-lactamase) (class B), and OXA-48 (oxacillinase, class D)—have been reported in NTS. Carbapenem resistance due to the production of extended spectrum- or AmpC β-lactamases combined with porin loss has also been detected in NTS. Horizontal gene transfer of carbapenemase-encoding genes (which are frequently located on self-transferable plasmids), together with co- and cross-selective adaptations, could have been involved in the development of carbapenem resistance by NTS. Once acquired by a zoonotic bacterium, resistance can be transmitted from humans to animals and from animals to humans through the food chain. Continuous surveillance of resistance to these “last resort” antibiotics is required to establish possible links between reservoirs and to limit the bidirectional transfer of the encoding genes between S. enterica and other commensal or pathogenic bacteria.
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spelling pubmed-60247232018-07-08 Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food Fernández, Javier Guerra, Beatriz Rodicio, M. Rosario Vet Sci Review Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical “last resort” antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli, and Enterobacter, which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS. Nevertheless, it has already been detected in isolates recovered from humans, companion animals, livestock, wild animals, and food. Five carbapenemases with major clinical importance—namely KPC (Klebsiella pneumoniae carbapenemase) (class A), IMP (imipenemase), NDM (New Delhi metallo-β-lactamase), VIM (Verona integron-encoded metallo-β-lactamase) (class B), and OXA-48 (oxacillinase, class D)—have been reported in NTS. Carbapenem resistance due to the production of extended spectrum- or AmpC β-lactamases combined with porin loss has also been detected in NTS. Horizontal gene transfer of carbapenemase-encoding genes (which are frequently located on self-transferable plasmids), together with co- and cross-selective adaptations, could have been involved in the development of carbapenem resistance by NTS. Once acquired by a zoonotic bacterium, resistance can be transmitted from humans to animals and from animals to humans through the food chain. Continuous surveillance of resistance to these “last resort” antibiotics is required to establish possible links between reservoirs and to limit the bidirectional transfer of the encoding genes between S. enterica and other commensal or pathogenic bacteria. MDPI 2018-04-08 /pmc/articles/PMC6024723/ /pubmed/29642473 http://dx.doi.org/10.3390/vetsci5020040 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fernández, Javier
Guerra, Beatriz
Rodicio, M. Rosario
Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
title Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
title_full Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
title_fullStr Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
title_full_unstemmed Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
title_short Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
title_sort resistance to carbapenems in non-typhoidal salmonella enterica serovars from humans, animals and food
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024723/
https://www.ncbi.nlm.nih.gov/pubmed/29642473
http://dx.doi.org/10.3390/vetsci5020040
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