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Association Between Blood Lipid Profiles and Atrial Fibrillation: A Case-Control Study

BACKGROUND: Dyslipidemia is the most frequent comorbidity in patients with cardiovascular disease. However, studies examining the relationship between blood lipid profiles and AF have produced inconsistent results. MATERIAL/METHODS: A total of 651 patients were enrolled into 3 groups: Healthy contro...

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Detalles Bibliográficos
Autores principales: Li, Zhi-Zhao, Du, Xin, Guo, Xue-yuan, Tang, Ri-bo, Jiang, Chao, Liu, Nian, Chang, San-shuai, Yu, Rong-hui, Long, De-yong, Bai, Rong, Sang, Cai-hua, Li, Song-nan, Dong, Jian-zeng, Ma, Chang-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024732/
https://www.ncbi.nlm.nih.gov/pubmed/29885277
http://dx.doi.org/10.12659/MSM.907580
Descripción
Sumario:BACKGROUND: Dyslipidemia is the most frequent comorbidity in patients with cardiovascular disease. However, studies examining the relationship between blood lipid profiles and AF have produced inconsistent results. MATERIAL/METHODS: A total of 651 patients were enrolled into 3 groups: Healthy controls (n=64), Paroxysmal AF (PAF; n=270), and Continuous AF (CAF; n=317). All enrolled patients underwent routine baseline 12-lead electrocardiography (ECG) and 24-h dynamic ECG along with blood testing, which included the following: complete metabolic panel, hepatic function, renal function, circulating thyroxine, fasting high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC). RESULTS: Patients with AF had significantly higher levels of triglycerides (TG), lower levels of LDL-C-c, and lower levels of HDL-C (p<0.05). TC (OR 0.979, p<0.9247) and TG (OR 0.945, p<0.6496) were negatively and linearly associated with PAF, while TG (OR 0.807, p=0.2042), LDL-C (OR 0.334, p=0.0036), and HDL-C (OR 0.136, p=0.0002) were negatively and linearly associated with CAF. CONCLUSIONS: Compared to healthy controls, patients with AF had lower blood lipid levels, especially LDL-c and HDL-c levels. Hypolipoproteinemia may increase patient susceptibility to developing AF.