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Live Bacterial Vectors—A Promising DNA Vaccine Delivery System

Vaccination is one of the most successful immunology applications that has considerably improved human health. The DNA vaccine is a new vaccine being developed since the early 1990s. Although the DNA vaccine is promising, no human DNA vaccine has been approved to date. The main problem facing DNA va...

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Detalles Bibliográficos
Autor principal: Yurina, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024733/
https://www.ncbi.nlm.nih.gov/pubmed/29570602
http://dx.doi.org/10.3390/medsci6020027
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author Yurina, Valentina
author_facet Yurina, Valentina
author_sort Yurina, Valentina
collection PubMed
description Vaccination is one of the most successful immunology applications that has considerably improved human health. The DNA vaccine is a new vaccine being developed since the early 1990s. Although the DNA vaccine is promising, no human DNA vaccine has been approved to date. The main problem facing DNA vaccine efficacy is the lack of a DNA vaccine delivery system. Several studies explored this limitation. One of the best DNA vaccine delivery systems uses a live bacterial vector as the carrier. The live bacterial vector induces a robust immune response due to its natural characteristics that are recognized by the immune system. Moreover, the route of administration used by the live bacterial vector is through the mucosal route that beneficially induces both mucosal and systemic immune responses. The mucosal route is not invasive, making the vaccine easy to administer, increasing the patient’s acceptance. Lactic acid bacterium is one of the most promising bacteria used as a live bacterial vector. However, some other attenuated pathogenic bacteria, such as Salmonella spp. and Shigella spp., have been used as DNA vaccine carriers. Numerous studies showed that live bacterial vectors are a promising candidate to deliver DNA vaccines.
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spelling pubmed-60247332018-07-05 Live Bacterial Vectors—A Promising DNA Vaccine Delivery System Yurina, Valentina Med Sci (Basel) Review Vaccination is one of the most successful immunology applications that has considerably improved human health. The DNA vaccine is a new vaccine being developed since the early 1990s. Although the DNA vaccine is promising, no human DNA vaccine has been approved to date. The main problem facing DNA vaccine efficacy is the lack of a DNA vaccine delivery system. Several studies explored this limitation. One of the best DNA vaccine delivery systems uses a live bacterial vector as the carrier. The live bacterial vector induces a robust immune response due to its natural characteristics that are recognized by the immune system. Moreover, the route of administration used by the live bacterial vector is through the mucosal route that beneficially induces both mucosal and systemic immune responses. The mucosal route is not invasive, making the vaccine easy to administer, increasing the patient’s acceptance. Lactic acid bacterium is one of the most promising bacteria used as a live bacterial vector. However, some other attenuated pathogenic bacteria, such as Salmonella spp. and Shigella spp., have been used as DNA vaccine carriers. Numerous studies showed that live bacterial vectors are a promising candidate to deliver DNA vaccines. MDPI 2018-03-23 /pmc/articles/PMC6024733/ /pubmed/29570602 http://dx.doi.org/10.3390/medsci6020027 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yurina, Valentina
Live Bacterial Vectors—A Promising DNA Vaccine Delivery System
title Live Bacterial Vectors—A Promising DNA Vaccine Delivery System
title_full Live Bacterial Vectors—A Promising DNA Vaccine Delivery System
title_fullStr Live Bacterial Vectors—A Promising DNA Vaccine Delivery System
title_full_unstemmed Live Bacterial Vectors—A Promising DNA Vaccine Delivery System
title_short Live Bacterial Vectors—A Promising DNA Vaccine Delivery System
title_sort live bacterial vectors—a promising dna vaccine delivery system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024733/
https://www.ncbi.nlm.nih.gov/pubmed/29570602
http://dx.doi.org/10.3390/medsci6020027
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