Cargando…

α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167)

The aim of this study is to investigate the potential inhibitory effect of α-chaconine and α-solanine on RL95-2 estrogen receptor (ER) positive human endometrial cancer cell line and to identify the effect of these glycoalkaloids on the Akt signaling and ERα. The cell proliferation profiles and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karaboğa Arslan, Ayşe Kübra, Yerer, Mükerrem Betül
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024735/ https://www.ncbi.nlm.nih.gov/pubmed/29799481 http://dx.doi.org/10.3390/nu10060672

Ejemplares similares

Solanaceae glycoalkaloids: α-solanine and α-chaconine modify the cardioinhibitory activity of verapamil
por: Chowański, Szymon, et al.
Publicado: (2022)

Development of New Antibodies and an ELISA System to Detect the Potato Alkaloids α-Solanine and α-Chaconine
por: Okada, Kohki, et al.
Publicado: (2023)

Liquid Chromatography Mass Spectrometry Quantification of α-solanine, α-chaconine, and Solanidine in Potato Protein Isolates
por: Nielsen, Søren D., et al.
Publicado: (2020)

Forensic analysis using ultra-high-performance liquid chromatography–tandem mass spectrometry with solid-phase extraction of α-solanine and α-chaconine in whole blood
por: Nara, Akina, et al.
Publicado: (2018)

A multifunctional enzyme portfolio for α-chaconine and α-solanine degradation in the Phthorimaea operculella gut bacterium Glutamicibacter halophytocola S2 encoded in a trisaccharide utilization locus
por: Wang, Wenqian, et al.
Publicado: (2022)

Relation between outcomes and expression of estrogen receptor-α phosphorylated at Ser(167) in endometrioid endometrial cancer
por: Kato, Eiichi, et al.
Publicado: (2014)

Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer
por: Voorneveld, Jim, et al.
Publicado: (2018)

Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine
por: Komoto, Tatiana Takahasi, et al.
Publicado: (2014)

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells
por: Chua, Boon Tin, et al.
Publicado: (2009)

Investigating the effect of visfatin on ERalpha phosphorylation (Ser118 and Ser167) and ERE-dependent transcriptional activity
por: Zangooei, Mohammad, et al.
Publicado: (2018)

Antitumor Efficacy of α-Solanine against Pancreatic Cancer In Vitro and In Vivo
por: Lv, Chongqing, et al.
Publicado: (2014)

α-Solanine inhibits growth and metastatic potential of human colorectal cancer cells
por: Yan, Xia, et al.
Publicado: (2020)

α-Chaconine Affects the Apoptosis, Mechanical Barrier Function, and Antioxidant Ability of Mouse Small Intestinal Epithelial Cells
por: He, Yuhua, et al.
Publicado: (2021)

Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3β (Ser9)/Nrf2 pathway
por: Lin, Miao, et al.
Publicado: (2023)

α-Solanine Causes Cellular Dysfunction of Human Trophoblast Cells via Apoptosis and Autophagy
por: Chen, Zhilong, et al.
Publicado: (2021)

Network pharmacology-based strategy to investigate the effect and mechanism of α-solanine against glioma
por: Wang, ChunPeng, et al.
Publicado: (2023)

α-Chaconine Facilitates Chondrocyte Pyroptosis and Nerve Ingrowth to Aggravate Osteoarthritis Progression by Activating NF-κB Signaling
por: Zhang, Zhiguo, et al.
Publicado: (2022)

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
por: Arawaka, Shigeki, et al.
Publicado: (2017)

Phosphorylated Akt Protein at Ser473 Enables HeLa Cells to Tolerate Nutrient-Deprived Conditions
por: Fathy, Moustafa, et al.
Publicado: (2017)

Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription
por: Lanucara, Francesco, et al.
Publicado: (2016)

Mdm20 Stimulates PolyQ Aggregation via Inhibiting Autophagy Through Akt-Ser473 Phosphorylation
por: Yasuda, Kunihiko, et al.
Publicado: (2013)

LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473
por: Zhang, Yuanjiao, et al.
Publicado: (2023)

Ser360 and Ser364 in the Kinase Domain of Tomato SlMAPKKKα are Critical for Programmed Cell Death Associated with Plant Immunity
por: Hwang, In Sun, et al.
Publicado: (2017)

Potential of Alpha-(α)-Solanine as a Natural Inhibitor of Fungus Causing Leaf Spot Disease in Strawberry
por: Xu, Ning, et al.
Publicado: (2023)

Report on Second International Conference on Natural Products for Cancer Prevention and Therapy Held in Kayseri, Turkey, 8–11 November 2017
por: Yerer, Mükerrem Betül, et al.
Publicado: (2017)

Ser o no ser : Del no ser al ser
por: García Durán, Alejandro
Publicado: (1999)

Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1
por: Chang, Chiung-Wen, et al.
Publicado: (2008)

PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway
por: Tsuchiya, A, et al.
Publicado: (2014)

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia
por: Shindo, Sawako, et al.
Publicado: (2020)

α-Solanine Inhibits Invasion of Human Prostate Cancer Cell by Suppressing Epithelial-Mesenchymal Transition and MMPs Expression
por: Shen, Kun-Hung, et al.
Publicado: (2014)

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival
por: Riaz, Anjum, et al.
Publicado: (2012)

Kainic Acid-Induced Seizures Modulate Akt (SER473) Phosphorylation in the Hippocampus of Dopamine D2 Receptor Knockout Mice
por: Dunleavy, Mark, et al.
Publicado: (2012)

Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation
por: Chen, Ke, et al.
Publicado: (2020)

Expression of Concern: Mdm20 Stimulates PolyQ Aggregation via Inhibiting Autophagy Through Akt-Ser473 Phosphorylation
Publicado: (2023)

A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
por: Liao, Sha, et al.
Publicado: (2020)

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
por: Heathcote, Helen R., et al.
Publicado: (2016)

Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice
por: Islam, M. M. Towhidul, et al.
Publicado: (2021)

α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo
por: Gu, Ting, et al.
Publicado: (2021)

PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive early breast cancer
por: Ishida, Naoko, et al.
Publicado: (2018)

Ser o no ser ; La escuela del amor
por: Gorostiza, Celestino
Publicado: (1935)

Cannot write session to /tmp/vufind_sessions/sess_re3nbjp25g52kie01t34i7te3l