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Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases

Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a dreadful pathogenic potential to cause a variety of community and hospital-acquired infections. The frequency of these infections is increasing and their treatment is becoming more difficult. The ability of S. a...

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Autores principales: Oliveira, Diana, Borges, Anabela, Simões, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024779/
https://www.ncbi.nlm.nih.gov/pubmed/29921792
http://dx.doi.org/10.3390/toxins10060252
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author Oliveira, Diana
Borges, Anabela
Simões, Manuel
author_facet Oliveira, Diana
Borges, Anabela
Simões, Manuel
author_sort Oliveira, Diana
collection PubMed
description Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a dreadful pathogenic potential to cause a variety of community and hospital-acquired infections. The frequency of these infections is increasing and their treatment is becoming more difficult. The ability of S. aureus to form biofilms and the emergence of multidrug-resistant strains are the main reasons determining the challenge in dealing with these infections. S. aureus' infectious capacity and its success as a pathogen is related to the expression of virulence factors, among which the production of a wide variety of toxins is highlighted. For this reason, a better understanding of S. aureus toxins is needed to enable the development of new strategies to reduce their production and consequently improve therapeutic approaches. This review focuses on understanding the toxin-based pathogenesis of S. aureus and their role on infectious diseases.
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spelling pubmed-60247792018-07-09 Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases Oliveira, Diana Borges, Anabela Simões, Manuel Toxins (Basel) Review Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a dreadful pathogenic potential to cause a variety of community and hospital-acquired infections. The frequency of these infections is increasing and their treatment is becoming more difficult. The ability of S. aureus to form biofilms and the emergence of multidrug-resistant strains are the main reasons determining the challenge in dealing with these infections. S. aureus' infectious capacity and its success as a pathogen is related to the expression of virulence factors, among which the production of a wide variety of toxins is highlighted. For this reason, a better understanding of S. aureus toxins is needed to enable the development of new strategies to reduce their production and consequently improve therapeutic approaches. This review focuses on understanding the toxin-based pathogenesis of S. aureus and their role on infectious diseases. MDPI 2018-06-19 /pmc/articles/PMC6024779/ /pubmed/29921792 http://dx.doi.org/10.3390/toxins10060252 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliveira, Diana
Borges, Anabela
Simões, Manuel
Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
title Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
title_full Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
title_fullStr Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
title_full_unstemmed Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
title_short Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
title_sort staphylococcus aureus toxins and their molecular activity in infectious diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024779/
https://www.ncbi.nlm.nih.gov/pubmed/29921792
http://dx.doi.org/10.3390/toxins10060252
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