Incobotulinumtoxin A for Sialorrhea in Neurological Disorders: A Real-Life Experience

Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez-Poles, Javier, Nedkova-Hristova, Velina, Escribano-Paredes, José Bernardo, García-Madrona, Sebastián, Natera-Villalba, Elena, Estévez-Fraga, Carlos, López-Sendón Moreno, José Luis, Avilés-Olmos, Icíar, Sánchez Díaz, Gema, Martínez Castrillo, Juan Carlos, Alonso-Canovas, Araceli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024805/
https://www.ncbi.nlm.nih.gov/pubmed/29843420
http://dx.doi.org/10.3390/toxins10060217
Descripción
Sumario:Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands. The severity of sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling Frequency Scale (DFS). Patients’ perceptions of clinical benefit were recorded via the Patient Global Impression of Improvement (PGI-I) scale. Following treatment, there was a significant difference in both the DFS and the DSS (p < 0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of patients.

Ejemplares similares